Organisation
Laboratory of Translational Genetics (VIB-KU Leuven)
Division
The overall aim of the research of the Laboratory of Translational Genetics, is to unravel the genetic predisposition to cancer and to annotate somatic changes in solid tumors with the ultimate aim to discover and functionally validate genetic biomarkers for cancer therapies.
Current researchers
1 - 8 of 8 results
- Diether Lambrechts (Responsible)
- Ayse Bassez (Member)
- Dóra Bihary (Member)
- Diether Lambrechts (Member)
- Aurelie Mechels (Member)
- Junbin Qian (Member)
- Pierre Van Mol (Member)
- Sam Vanmassenhove (Member)
Projects
1 - 10 of 71
- Liquid biopsy and HRD testing in ovarian cancerFrom4 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Decoding the penile cancer tumor microenvironment: heterogeneity of tumor-associated epithelial cell states, it's relationship with HPV, and it's role in prognosis and therapy response.From1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Integration of Spatial Transcript- and Proteomics Techniques with Pan-cancer single cell RNA-sequencing data to interrogate the impact of immunotherapy on the Tumor Microenvironment (TME)From9 May 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- An Integrated Spatial Atlas of the Tumor Micro-environment of Early Non-Small Cell Lung CancerFrom16 Mar 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Abemaciclib and letrozole in ER positive rare ovarian cancerFrom1 Mar 2023 → TodayFunding: Foundations, funds and other with scientific goal
- SymBioSys: Computationally mapping genomic heterogeneity from long read sequencing dataFrom1 Oct 2022 → TodayFunding: BOF - projects
- Refining the role of dual checkpoint inhibition in advanced lung cancer: a single-cell approachFrom5 Oct 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Multiomic Integration of cell-free DNA profiles to Advance Disease OutcomeFrom1 Oct 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
- Connecting Single-cell Immune Profiling in Peripheral Blood with Intratumoral T Cell Expansion in Breast Cancer Upon Checkpoint ImmunotherapyFrom24 Aug 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Developing personalized treatment for advanced penile cancer trough establishment of Patient-Derived Tumor Xenografts (PDTXs).From9 Aug 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
31 - 40 of 664
- (Epi)genetic variation in ageing of metabolic fitness(2015)
Authors: Maarten Caspers, Diether Lambrechts, Johan Lefevre, Martine Thomis
Pages: 38 - 38 - Identification of nine new susceptibility loci for endometrial cancer(2018)
Authors: Frédéric Amant, Daniela Annibali, Diether Lambrechts, Adriaan Vanderstichele
- Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci(2017)
Authors: Diether Lambrechts
Pages: 524 - 535 - Olmsted syndrome: exploration of the immunological phenotype(2013)
Authors: Dina Danso-Abeam, James Dooley, Lien Van Eyck, Esther Hauben, Marc Van De Velde, Chris Van Geet, Heidi Schaballie, Diether Lambrechts, Dean Franckaert, Stephanie Humblet-Baron, et al.
- Genetic markers of bevacizumab-induced hypertension(2014)
Authors: Diether Lambrechts, Matthieu Moisse, Eric Van Cutsem, Peter Carmeliet
Pages: 685 - 94 - GENETICS IN ANGIOGENESIS AND ITS INFLUENCE ON CLINICAL DECISION MAKING(2009)
Authors: Diether Lambrechts
Pages: 20 - 20 - Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade(2014)
Authors: Caroline Weltens, Beppe Floris, Matthieu Moisse, Diether Lambrechts
Pages: 6034 - 46 - Evaluating the ovarian cancer gonadotropin hypothesis: a candidate gene study(2015)
Authors: Ignace Vergote, Els Van Nieuwenhuysen, Diether Lambrechts
Pages: 542 - 8 - A large-scale assessment of two-way SNP interactions in breast cancer susceptibility using 46 450 cases and 42 461 controls from the breast cancer association consortium(2014)
Authors: Diether Lambrechts, Beppe Floris, Karin Leunen
Pages: 1934 - 1946 - A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population(2010)
Authors: Diether Lambrechts, Robert Paridaens
Pages: 885 - 892