Organisation
Laboratory of Translational Genetics (VIB-KU Leuven)
Division
The overall aim of the research of the Laboratory of Translational Genetics, is to unravel the genetic predisposition to cancer and to annotate somatic changes in solid tumors with the ultimate aim to discover and functionally validate genetic biomarkers for cancer therapies.
Current researchers
1 - 8 of 8 results
- Diether Lambrechts (Responsible)
- Ayse Bassez (Member)
- Dóra Bihary (Member)
- Diether Lambrechts (Member)
- Aurelie Mechels (Member)
- Junbin Qian (Member)
- Pierre Van Mol (Member)
- Sam Vanmassenhove (Member)
Projects
1 - 10 of 72
- Liquid biopsy and HRD testing in ovarian cancerFrom4 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Decoding the penile cancer tumor microenvironment: heterogeneity of tumor-associated epithelial cell states, it's relationship with HPV, and it's role in prognosis and therapy response.From1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Integration of Spatial Transcript- and Proteomics Techniques with Pan-cancer single cell RNA-sequencing data to interrogate the impact of immunotherapy on the Tumor Microenvironment (TME)From9 May 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- An Integrated Spatial Atlas of the Tumor Micro-environment of Early Non-Small Cell Lung CancerFrom16 Mar 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Abemaciclib and letrozole in ER positive rare ovarian cancerFrom1 Mar 2023 → TodayFunding: Foundations, funds and other with scientific goal
- SymBioSys: Computationally mapping genomic heterogeneity from long read sequencing dataFrom1 Oct 2022 → TodayFunding: BOF - projects
- Refining the role of dual checkpoint inhibition in advanced lung cancer: a single-cell approachFrom5 Oct 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Multiomic Integration of cell-free DNA profiles to Advance Disease OutcomeFrom1 Oct 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
- Connecting Single-cell Immune Profiling in Peripheral Blood with Intratumoral T Cell Expansion in Breast Cancer Upon Checkpoint ImmunotherapyFrom24 Aug 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Developing personalized treatment for advanced penile cancer trough establishment of Patient-Derived Tumor Xenografts (PDTXs).From9 Aug 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
11 - 20 of 668
- Clearseq1-4 classifier in localized and metastatic clear-cell renal cell carcinoma (ccRCC)(2022)
Authors: Lisa Kinget, Diether Lambrechts, Bram Boeckx, Maarten Albersen, Benoit Beuselinck
Pages: S1222 - S1223 - Genetische profielscores en leeftijdsgerelateerde veranderingen in krachtparameters bij Vlaamse volwassenen na een tienjarie follow-up(2016)
Authors: Ruben Charlier, Sara Knaeps, Diether Lambrechts, Martine Thomis
Pages: 70 - 79 - European experts consensus: BRCA/homologous recombination deficiency testing in first-line ovarian cancer(2022)
Authors: Ignace Vergote, Diether Lambrechts
Pages: 276 - 287 - CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers(2021)
Authors: Bram Boeckx, Beppe Floris, Diether Lambrechts, Hans Wildiers
Pages: 842 - 854 - Multivariable regression analysis of febrile neutropenia occurrence in early breast cancer patients receiving chemotherapy assessing patient-related, chemotherapy-related and genetic risk factors(2014)
Authors: Robert Paridaens, Anne-Sophie Dieudonné, Sigrid Hatse, Patrick Neven, Diether Lambrechts, Hans Wildiers
Pages: 201 - No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer(2016)
Authors: Diether Lambrechts, Sandrina Lambrechts, Patrick Neven, Benoit Beuselinck, Dominiek Smeets, Els Van Nieuwenhuysen, Ignace Vergote, Caroline Weltens
Pages: 386 - 401 - Gene-Environment Interactions Relevant to Estrogen and Risk of Breast Cancer: Can Gene-Environment Interactions Be Detected Only among Candidate SNPs from Genome-Wide Association Studies?(2021)
Authors: Diether Lambrechts
- Neuronal FLT1 receptor and its selective ligand VEGF-B protect against retrograde degeneration of sensory neurons(2011)
Authors: An Verheyen, Koen Poesen, Manu Beerens, Theo Meert, Peter Carmeliet, Diether Lambrechts
Pages: 1461 - 1473 - CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells(2017)
Authors: Els Wauters, Johan Vansteenkiste, Diether Lambrechts
Pages: 168 - 172 - Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma (vol 21, pg 946, 2015)(2016)
Authors: Dany Nassar, Mathilde latil, Bram Boeckx, Diether Lambrechts, Cedric Blanpain
Pages: 217 - 217