Organisation
Laboratory of Translational Genetics (VIB-KU Leuven)
Division
The overall aim of the research of the Laboratory of Translational Genetics, is to unravel the genetic predisposition to cancer and to annotate somatic changes in solid tumors with the ultimate aim to discover and functionally validate genetic biomarkers for cancer therapies.
Current researchers
1 - 8 of 8 results
- Diether Lambrechts (Responsible)
- Ayse Bassez (Member)
- Dóra Bihary (Member)
- Diether Lambrechts (Member)
- Aurelie Mechels (Member)
- Junbin Qian (Member)
- Pierre Van Mol (Member)
- Sam Vanmassenhove (Member)
Projects
1 - 10 of 72
- Liquid biopsy and HRD testing in ovarian cancerFrom4 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Decoding the penile cancer tumor microenvironment: heterogeneity of tumor-associated epithelial cell states, it's relationship with HPV, and it's role in prognosis and therapy response.From1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Integration of Spatial Transcript- and Proteomics Techniques with Pan-cancer single cell RNA-sequencing data to interrogate the impact of immunotherapy on the Tumor Microenvironment (TME)From9 May 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- An Integrated Spatial Atlas of the Tumor Micro-environment of Early Non-Small Cell Lung CancerFrom16 Mar 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Abemaciclib and letrozole in ER positive rare ovarian cancerFrom1 Mar 2023 → TodayFunding: Foundations, funds and other with scientific goal
- SymBioSys: Computationally mapping genomic heterogeneity from long read sequencing dataFrom1 Oct 2022 → TodayFunding: BOF - projects
- Refining the role of dual checkpoint inhibition in advanced lung cancer: a single-cell approachFrom5 Oct 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Multiomic Integration of cell-free DNA profiles to Advance Disease OutcomeFrom1 Oct 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
- Connecting Single-cell Immune Profiling in Peripheral Blood with Intratumoral T Cell Expansion in Breast Cancer Upon Checkpoint ImmunotherapyFrom24 Aug 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Developing personalized treatment for advanced penile cancer trough establishment of Patient-Derived Tumor Xenografts (PDTXs).From9 Aug 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
41 - 50 of 668
- Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer(2013)
Authors: Ignace Vergote, Sandrina Lambrechts, Diether Lambrechts
Pages: 1628 - Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer(2015)
Authors: Diether Lambrechts, Sandrina Lambrechts, Els Van Nieuwenhuysen, Ignace Vergote
Pages: 8234 - Molecularly targeted therapies for colorectal cancer: Strategies for implementing translational research in clinical trials(2010)
Authors: Diether Lambrechts, Eric Van Cutsem
Pages: 703 - 11 - Fibroblast Growth Factor Receptor-2 Polymorphism rs2981582 is Correlated With Progression-free Survival and Overall Survival in Patients With Metastatic Clear-cell Renal Cell Carcinoma Treated With Sunitinib(2019)
Authors: Maxime Vanmechelen, Diether Lambrechts, Annelies Verbiest, Patrick Schöffski, Herlinde Dumez, Evelyne Lerut, Maarten Albersen, Benoit Beuselinck
Pages: E235 - E246 - Genetic biomarkers in the VEGF pathway predicting response to anti-VEGF therapy in age-related macular degeneration(2019)
Authors: Bernard Thienpont, Diether Lambrechts
- Genetic alterations guiding ovarian cancer therapy(2015)
Authors: Ignace Vergote, Diether Lambrechts
- Characterization of patient-derived tumor xenograft models of endometrial cancer for preclinical evaluation of targeted therapies(2015)
Authors: Jeroen Depreeuw, Stefanie Schrauwen, Daniela Annibali, Debby Thomas, Katrien Konings, Philippe Moerman, Ignace Vergote, Diether Lambrechts, Frédéric Amant
Pages: 118 - 26 - GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer(2013)
Authors: Diether Lambrechts, Sandrina Lambrechts, Ignace Vergote
Pages: 362 - 70 - Genomic Characterisation and Response to Trastuzumab and Paclitaxel in Advanced or Recurrent HER2-positive Endometrial Carcinoma(2016)
Authors: Jeroen Depreeuw, Stijn Moens, Daniela Annibali, Tine Cuppens, Philippe Moerman, Diether Lambrechts, Frédéric Amant
Pages: 5381 - 5384 - Genetic variation in the lymphotoxin-α- (LTA-)/tumor necrosis-factor-α- (TNFα-) locus as a risk factor for idiopathic achalasia(2013)
Authors: Mira Wouters, Diether Lambrechts, Isabelle Cleynen, Jan Tack, Séverine Vermeire, Guy Boeckxstaens
Pages: 1401 - 1409