Publicaties
HNA and ANA high-affinity arrays for detections of DNA and RNA single-base mismatches KU Leuven
Evaluation of bisulfite kits for DNA methylation profiling in terms of DNA fragmentation and DNA recovery using digital PCR Universiteit Gent
Towards harmonization of DNA metabarcoding for monitoring marine macrobenthos: The effect of technical replicates and pooled DNA extractions on species detection Instituut voor Landbouw-, Visserij- en Voedingsonderzoek Universiteit Gent
Retrospective study of the impact of miniSTRs on forensic DNA profiling of touch DNA samples Universiteit Gent
Micronuclei as biomarkers of DNA damage, aneuploidy, inducers of chromosomal hypermutation and as sources of pro-inflammatory DNA in humans Vrije Universiteit Brussel
Micronuclei (MNi) are among the most widely studied biomarkers of DNA damage and chromosomal instability in humans. They originate from chromosome fragments or intact chromosomes that are not included in daughter nuclei during mitosis. The main reasons for their formation are a lack of functional centromere in the chromosome fragments or whole chromosomes or defects in one or more of the proteins of the mitotic system that, consequently, ...
The Trypanosoma cruzi satellite DNA OligoC-TesT and Trypanosoma cruzi kinetoplast DNA OligoC-TesT for diagnosis of Chagas disease Instituut voor Tropische Geneeskunde
BACKGROUND: The Trypanosoma cruzi satellite DNA (satDNA) OligoC-TesT is a standardised PCR format for diagnosis of Chagas disease. The sensitivity of the test is lower for discrete typing unit (DTU) TcI than for TcII-VI and the test has not been evaluated in chronic Chagas disease patients.
METHODOLOGY/PRINCIPAL FINDINGS: We developed a new prototype of the OligoC-TesT based on kinetoplast DNA (kDNA) detection. We evaluated the satDNA ...
The absence of C-5 DNA methylation in Leishmania donovani allows DNA enrichment from complex samples Instituut voor Tropische Geneeskunde Universiteit Antwerpen
Cytosine C5 methylation is an important epigenetic control mechanism in a wide array of eukaryotic organisms and generally carried out by proteins of the C-5 DNA methyltransferase family (DNMTs). In several protozoans, the status of this mechanism remains elusive, such as in Leishmania, the causative agent of the disease leishmaniasis in humans and a wide array of vertebrate animals. In this work, we showed that the Leishmania donovani genome ...