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Franck Dumetz

  • Trefwoorden:B780-tropische-geneeskunde
  • Gebruikers van onderzoeksexpertise:

    My main research line is to understand the molecular mechanisms involved in the antimonials resistance in L. donovani in the particular Indian Sub-Continent context. We address this particular research question by artificially over-expressing gene that are naturally amplified in clinical isolates but also by inducting in vitro and in vivo resistance to antimonials. Another part of the project is to understand the genome structure of Leishmania and how the genome flexibility is involve in drug resistance and adaptation to environmental changes.