Projects
Synthesis of diamino acid derivatives with a cyclopropane or aziridine skeleton and their application in the synthesis of potential physiologically active alpha, gamma-dimainobutyric acid derivatives Ghent University
The synthesis of constrained x, B- or x, Y-diamino acid derivatives as building blocks for new substituted 2,4-diaminobutyric acid derivatives is of great importance in medicinal and agricultural chemistry. This research concerns the development of stereoselective syntheses and biochemical evaluation of new derivatives of 1,2-diaminocyclopropane-1-carboxylic acid, 2-amino-2-aziridin-2-ylacetic acid and 2-amino-3-aziridin-2-ylpropionic acid ...
A new method for the synthesis of highly substituted pyrroles and application to the synthesis of fluorescing dyes and expanded porphyrins KU Leuven
Synthesis and evaluation of new antimalarials tackling a unique biosynthetic pathway for isoprenoid synthesis in P. falciparum. Ghent University
A mevalonate independent pathway for isoprenoid biosynthesis, the so-called MEP pathway, has been discovered recently and validated as new drug target for the development of antimalarials. Fosmidomycin, a phosphonate that interferes with this pathway through inhibition of DOXP reductoisomerase, is a promising clinically effective antimalarial agent. This project aims at the development of of enantiomerically pure alpha-substituted ...
Synthesis and evaluation of microcin C analogs as aminoacyl-tRNA synthetase inhibitors. KU Leuven
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Design, Synthesis and Biochemical evaluation of novel serine protease activity-based probes. University of Antwerp
Rational design and synthesis of non-hallucinogenic psilocin analogues as selective 5-HT2A receptor agonists with therapeutic potential Ghent University
Depression has become a major socio-economic burden. This mental disorder affects 5% of the adults and it is a major contributor to long-term disability and disease. It has become clear that first-line antidepressants such as SSRIs, SNRIs, and NRIs are not effective enough; 30% of adults relapse after treatment and patients often need to deal with serious side effects. There is a clear need for better therapeutics. Several studies on ...
QSAR directed design, synthesis and evaluation of anti-invasive chalcones and related heterocyclic compounds Ghent University
Invasion and metastasis are the foremost causes of the fatal outcome of cancer and accordingly pose a main challenge in oncology. Using a predictive QSAR-model as a rationale and an in vitro assay as verification, the objective of this project is to synthesise new potent anti-invasive agents amongst the classes of chalcones and related heterocyclic compounds.
Microporous oxides and renewable materials synthesis. KU Leuven
The proposed research plan focuses on high-performance material synthesis, in the context of catalysis. The largest, core part of this material research program is dedicated to the synthesis of microporous tetrahedral oxides, mostly zeolites and zeotypes, for use as catalysts in sustainable chemistry. This part is entitled ZEOSYNTHECA - zeolite synthesis for enhanced catalytic action. Specifically we focus on catalytic processes and materials ...