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Researcher
Arthur Van Aerschot
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences, Bioinformatics and computational biology
Affiliations
- Medicinal Chemistry (Rega Institute) (Division)
Member
From1 Oct 1999 → 30 Sep 2022
Projects
1 - 10 of 19
- Crystallographic facility for target-based drug designFrom1 May 2020 → TodayFunding: FWO International research infrastructure (IRI)
- Development of new antimicrobials: Rational design of polyomavirus and mycobacterial inhibitorsFrom28 Aug 2019 → 28 Aug 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Development of a comprehensive platform for targeting redox homeostasis in Mycobacterium tuberculosis.From1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- Structure-guided design and development of antivirals targeting BK polyomavirus capsidFrom1 Oct 2018 → 30 Sep 2023Funding: IOF - Industrial Research Fund, Fund Recuperation Fiscal Exemption, BOF - Concerted Research Project from 1994
- Tyrosine-tRNA synthetase as target for the development of new antibacterial lead structuresFrom1 Sep 2018 → 1 Sep 2019Funding: Own budget, for example: patrimony, inscription fees, gifts
- In vivo molecular ion channel imaging.From1 May 2018 → 30 Sep 2022Funding: FWO Odysseus
- Structure-based design of new antitubercular medicinesFrom1 Oct 2017 → 30 Sep 2019Funding: BOF - Bilateral scientific cooperation
- Structural Characterization of Aminoacyl-tRNA Synthetase Inhibitors as Antibiotics and Tools for Enzyme Mechanistic StudiesFrom1 Oct 2016 → 23 Sep 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- High throughput analysis of biomolecular interactionsFrom1 May 2016 → 30 Apr 2020Funding: FWO Medium Size Research Infrastructure
- Synthesis and biological evaluation of albomycin and aminoacyl sulfonamide analogues as potential aaRS inhibitors.From1 Oct 2015 → 30 Sep 2018Funding: FWO fellowships
Publications
1 - 10 of 97
- Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip(2022)
Authors: Sergei Strelkov, Arthur Van Aerschot
- Discovery of novel druggable pockets on polyomavirus VP1 through crystallographic fragment-based screening to develop capsid assembly inhibitors(2022)
Authors: Evgenii Osipov, Arthur Van Aerschot, Sergei Strelkov
- Towards Novel 3-Aminopyrazinamide-Based Prolyl-tRNA Synthetase Inhibitors: In Silico Modelling, Thermal Shift Assay and Structural Studies(2021)
Authors: Luping Pang, Sergei Strelkov, Arthur Van Aerschot
- Aminoacyl-tRNA Synthetases as Valuable Targets for Antimicrobial Drug Discovery.(2021)
Authors: Luping Pang, Arthur Van Aerschot
- Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors(2020)
Authors: Luping Pang, Steff De Graef, Eveline Lescrinier, Jef Rozenski, Sergei Strelkov, Arthur Van Aerschot
- Structural Characterization of Aminoacyl-tRNA Synthetase Inhibitors as Antibiotics and Tools for Enzyme Mechanistic Studies(2020)
Authors: Luping Pang, Arthur Van Aerschot, Sergei Strelkov, Stephen Weeks
- Synthesis and structural insights into the binding mode of the albomycin delta 1 core and its analogues in complex with their target aminoacyl-tRNA synthetase(2020)
Authors: Luping Pang, Steff De Graef, Sergei Strelkov, Arthur Van Aerschot
- Structural studies of aminoacyl-tRNA synthetases: development of new antibiotics(2020)
Authors: Steff De Graef, Sergei Strelkov, Arthur Van Aerschot, Stephen Weeks
- Synthesis and Biological Evaluation of Lipophilic Nucleoside Analogues as Inhibitors of Aminoacyl-tRNA Synthetases(2019)
Authors: Manesh Nautiyal, Steff De Graef, Luping Pang, Jef Rozenski, Arthur Van Aerschot
- Imaging the early steps of HIV-1 replication by labelling integrase and viral DNA(2019)
Authors: Flore De Wit, Zeger Debyser, Arthur Van Aerschot, Frauke Christ