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Development of a click chemistry based synthetic methodology for the synthesis of innovative potential lead compounds and/or chemical probes.
Several projects in the Laboratory for Medicinal Chemistry rely on click chemistry (1) as an essential aspect of bio-orthogonal derivatisation of proteins under physiological conditions or (2) as an efficient tool for the construction of innovative biologically active compounds. The candidate will apply his expertise in this domain to support and develop these ongoing projects. Additionally, novel approaches to overcome current boundaries in the domain of click chemistry will be investigated.
Date:1 Oct 2009 → 30 Sep 2010
Keywords:CLICK CHEMISTRY, INHIBITOR DESIGN, PROBE DESIGN, MEDICINAL CHEMISTRY
Disciplines:Chemical product design and formulation, Biomaterials engineering