1 - 10 of 615 results
Catenins: role in the functioning of the skeleton as an endocrine organ? KU Leuven
Diseases such as diabetes, obesity and osteoporosis involve complex effects on multiple organ systems. Manifestations in these pathophysiological conditions underscore the regular association between impaired energy metabolism and reduced bone mass and increased bone marrow adiposity, emphasizing the significance of the interactions between the classical metabolic tissues, bone and bone marrow fat. Evidence indicates that the skeleton ...
Cellular, molecular and endocrine mechanisms contributing to the functioning of the skeleton in whole-body glucose homeostasis KU Leuven
Metabolic disorders such as osteoporosis, obesity and diabetes represent a growing global epidemic. Ample links exist between these conditions, particularly underscoring the regular association of diseases of energy metabolism with skeletal complications. Conversely, the skeleton itself represents an endocrine organ integrated in the regulation of whole-body energy homeostasis. Understanding the cellular and molecular mechanisms involved in ...
Interplay between the skeleton and glucose homeostasis in the context of type 2 diabetes mellitus KU Leuven
Metabolic disorders such as osteoporosis, obesity and diabetes represent a global health concern, affecting millions of people worldwide. These conditions are linked in many ways. Type 2 diabetes mellitus (T2DM) impacts negatively on glucose homeostasis and multiple organs, including the skeleton, typically leading to poor bone quality, increased fracture risk, and impaired bone regeneration. Conversely, bone itself also affects energy ...
Design from nature: study of the seahorse skeleton and its possible application in industrial design. Ghent University
Through milions of years of evolution organisms have finetuned their design to their environment, often yielding elegant solutions to problems similar to engineering ones. Seahorses have a stiff bony skeleton, yet their tail remains extremely flexible. This project will investigate the morphology and biomechanics of the tail skeleton of seahorses (strenght, mobility and prehension) and look for engineering applications.
External moisture buffering air sealing systems for robust low energy wood skeleton structures. KU Leuven
The development of innovative, easy-to-realize, cost-effective, sustainable construction systems with an external airshade for low-energy wood skeleton constructions.
Drafting GRB skeleton specifications for the inventory of sewerage infrastructure (AWIS IMKL) and for underground cables and pipelines Ghent University
Computer Aided Designed and Manufactured Custom Implants of the Cranio-Maxillofacial Skeleton KU Leuven
This research especially focuses on the medical implants, manufactured by 3D printing, used in cranio-maxillofacial surgery.
Skull defects come in different sizes and a new classification is proposed that can be used in clinical and scientific setting.
New fixation technologies enable easier and faster fixation of custom cranial implants to the remaining skull bone.Verification is performed by FEM analysis and pull-out ...
Synthesis of diamino acid derivatives with a cyclopropane or aziridine skeleton and their application in the synthesis of potential physiologically active alpha,gamma-diaminobutyric acid derivates Ghent University
The synthesis of constrained A, B- or A, Y-diamino acid derivatives as building blocks for new substituted 2,4-diaminobutyric acid derivatives is of great importance in medicinal and agricultural chemisrty. This research concerns the development of stereoselective syntheses and biochemical evaluation of new derivatives of 1,2-diaminocyclopropane-1-carboxylic acid and also the stufdy of their ring opening reactions towards potentially ...