Synthesis of diamino acid derivatives with a cyclopropane or aziridine skeleton and their application in the synthesis of potential physiologically active alpha,gamma-diaminobutyric acid derivatives.

Objectives of the project:- Development and optimization of the stereoselective synthesis of new derivatives of 1,2-diaminocyclopropane-1-carboxylic acid, 2-amino-2-aziridin-2-ylacetic acid and 2-amino-3-aziridin-2-ylpropionic acid.- Development of ring opening reactions of 1,2-diaminocyclopropane-1-carboxylic acid derivatives, 2-amino-2-aziridin-2-ylacetic acid derivatives and 2-amino-3-aziridin-2-ylpropionic acid derivatives towards potentiallyphysiologically active amino acid derivatives among which 2,4-diaminobutyric acid derivatives.- Biological screening of new conformationally constrained diamino acid derivatives and corresponding ring opened compounds.

Keywords:AGROCHEMICALS, ORGANIC CHEMISTRY, PROTEINS

Disciplines:Organic chemistry, Other chemical sciences, Biochemistry and metabolism, Systems biology, Medical biochemistry and metabolism, Agricultural plant production

Project type:Collaboration project