Projects
Single-Cell Analysis and Metabolic Modelling of Pairwise Interactions in the Gut Microbiome KU Leuven
The gut microbiota is a complex ecosystem that houses a diverse array of microorganisms, including eukaryotic cells, bacteria and viruses, and plays a crucial role in human health. Its functions include breaking down dietary fibres, producing vitamins, and protecting against pathogens. However, deciphering the role of the gut microbiota in disease remains challenging due to its size, diversity, and complexity, as well as its variability ...
High-content in-toto organoid profiling with single-cell resolution using deep learning-enhanced analysis. University of Antwerp
Development of a statistical framework for the analysis of single-cell multiomics datasets: towards a molecular atlas of the development of human preimplantation embryos. KU Leuven
The first cell cycles of human life are commonly subject to genome instability. However, the causes and consequences of the genetic alterations in the cells of the developing embryo remain to be investigated. Also the epigenetic landscape –i.e. modifications to the DNA that do not change the DNA-sequence but which can be heritable and control the expression of genes in the cells– is remodeled during early development of a human embryo. This ...
Antibiotic tolerance in Escherichia coli: functional characterisation and single-cell analysis of stochastic gene expression of a new persistence gene. KU Leuven
Unraveling the association between adiposity and breast cancer biology by in silico analysis of bulk and single-cell omics data KU Leuven
Breast cancer (BC) is one of the most common forms of cancer, affecting 2.1 million women each year globally, while also having a considerably high mortality rate – approximately 30% in 2018 according to WHO. Obesity is another medical problem that is becoming a great concern due to its increasing prevalence (3 times between 1975 and 2016 worldwide). The association between an increased risk and/or poor prognosis of BC and obesity has been ...
Microfluidics for single-cell omics. the C1 Single-Cell Auto Prep System, BioMark HD System and IFC controllers (Fluidigm) for single-cell analyses KU Leuven
Advances in whole-genome and whole-transcriptome amplification have permitted the sequencing of the DNA and RNA present in a single cell, offering a window into the extent and nature of genomic and transcriptomic heterogeneity which occurs in both normal development and disease. Single-cell approaches are revolutionising our capacity to understand the scale of genomic, epigenomic and transcriptomic diversity that occurs during the lifetime of ...
Understanding inherited and acquired genetic variation in Parkinson's disease through single-cell multi-omics analysis: a unique data resource. KU Leuven
Understanding gene expression pertubation by inheritde genetic variants of GWAS PD-risk loci. Identifying nature and roles of somatic CNV's in PD-etiopathology. Functional characterisation of eQTL and somatically mutated genes
Bioinformatics for single-cell sequence and in situ RNA analytics to study cell niches and cell-cell interaction KU Leuven
single-cell RNA-seq procedures alone are insufficient to deliver comprehensive insight in organ cell atlases in health and disease. Indeed, as most of our organ functions are executed by the concerted action of individual cells in a spatially organized context, it is paramount to research single cells in their native spatial context. This is not only important to understand normal organ development and function, but also to investigate how ...