Organisation
Laboratory for Translational Breast Cancer Research
Division
Part of the Department of Oncology that fosters synergy in innovative oncological research. By creating a close link between bed and bench and by capitalizing on advanced technologies, our researchers aim to unravel key molecular mechanisms underlying the development and progression of cancer and to maximize opportunities to translate these findings into better clinical biomarkers, adaptive strategies and innovative treatments.
Current researchers
1 - 10 of 13 results
- Christine Desmedt (Responsible)
- Kristien Borremans (Member)
- Maxim De Schepper (Member)
- Christine Desmedt (Member)
- Tatjana Geukens (Member)
- Edoardo Isnaldi (Member)
- Sophia Leduc (Member)
- Ha Linh Nguyen (Member)
- Anirudh Pabba (Member)
- François Richard (Member)
Projects
1 - 10 of 23
- Atlas of therapeutic targets in metastatic breast cancer.From1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- MetLob: A post-mortem tissue donation study dedicated to Metastatic Lobular breast cancerFrom1 Jan 2023 → TodayFunding: Foundations, funds and other with scientific goal
- Impact of adiposity and lifestyle on breast cancer biology and treatment response.From7 Oct 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Histopathological heterogeneity of metastatic breast cancerFrom1 Oct 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Clinical and molecular heterogeneity of triple-negative breast cancerFrom1 Oct 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Molecular characterization of the tumor microenvironment of breast cancer metastasesFrom11 Oct 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- UPTIDER (UZ/KU Leuven Program for post-mortem Tissue Donation to Enhance Research), a unique setting to unravel treatment resistance and disease progression in patients with breast cancer.From1 Oct 2021 → TodayFunding: BOF - projects
- LIQUIDEVO: Unravelling breast cancer heterogeneity, progression and treatment resistance in the context of a rapid post-mortem institutional tissue donation program using phylogenetic reconstruction algorithms and an Open Science approach.From1 Oct 2021 → TodayFunding: FWO senior postdoctoral fellowship
- Facing Adiposity in personalizing Treatment of Breast Cancer PatientsFrom1 Mar 2021 → TodayFunding: H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
- Clinical, experimental and molecular characterization of liver metastases from breast cancer patients.From1 Mar 2021 → TodayFunding: Foundations, funds and other with scientific goal
Publications
1 - 10 of 141
- Ovarian Function and Fertility Preservation in Breast Cancer: Should Gonadotropin-Releasing Hormone Agonist be administered to All Premenopausal Patients Receiving Chemotherapy?(2019)
Authors: François Richard
- Tally-2.0: upgraded validator of tandem repeat detection in protein sequences(2020)
Authors: François Richard
Pages: 3260 - 3262 - The impact of parity and age of first full term pregnancy on the prevalence of invasive lobular carcinoma in patients with breast cancer(2023)
Authors: Karen Van Baelen, François Richard, Beppe Floris, Hans Wildiers, Ines Nevelsteen, Patrick Neven, Christine Desmedt
- The genomic landscape of carcinomas with mucinous differentiation(2021)
Authors: Christine Desmedt
- Tumor characteristics and outcome by androgen receptor expression in triple-negative breast cancer patients treated with neo-adjuvant chemotherapy(2019)
Authors: Lynn Jongen, Beppe Floris, Hans Wildiers, Frank Claessens, François Richard, Annouschka Laenen, Christine Desmedt, Kevin Punie, Ann Smeets, Ignace Vergote, et al.
Pages: 699 - 708 - Association between reproductive factors (parity and age first full term birth) and the frequency of estrogen receptor negative breast cancer according to age at diagnosis(2023)
Authors: Karen Van Baelen, Annouschka Laenen, Christine Desmedt, Beppe Floris, Hans Wildiers, Ines Nevelsteen, Patrick Neven
- Breast cancer diagnosed during pregnancy is associated with enrichment of non-silent mutations, mismatch repair deficiency signature and mucin mutations(2018)
Authors: Bastien Nguyen, David Venet, Hatem A Azim, David Brown, Christine Desmedt, Matteo Lambertini, Samira Majjaj, Giancarlo Pruneri, Fedro Peccatori, Martine Piccart, et al.
- Microscopic tumor foci in axillary lymph nodes may reveal the recurrence dynamics of breast cancer(2019)
Authors: Christine Desmedt
- Integrative proteomic and gene expression analysis identify potential biomarkers for adjuvant trastuzumab resistance: analysis from the Fin-her phase III randomized trial(2015)
Authors: Christine Desmedt, Patrick Neven
Pages: 30306 - 16 - Comprehensive evaluation of methods to assess overall and cell-specific immune infiltrates in breast cancer(2019)
Authors: Christine Desmedt