Afwerkersbeurs Emmanuel Van der Schueren Karolina: Characterization of an aggressive and microbiota-dependent colon cancer model Ghent University
Colorectal cancer (CRC) is a frequently lethal disease with very heterogeneous outcomes and drug responses. We recently developed a new, fast and fully penetrant in vivo mouse model of spontaneous CRC based on the lEC-specific mono-allelic expression of the EMT transcription factor ZEB2. ZEB2, an E-box binding transcription factor, is a crucial driver of epithelial-to-mesenchymal transition (EMT). ZEB2 was initially described as a factor ...