Towards a PD biomarker guided therapy for patients with peritoneal carcinomatosis: combining patient-derived xenograft models and translational PKPD modeling to pave the way for a new paradigm in intraperitoneal chemotherapy Ghent University
Nowadays, patients with tumor metastases in the abdominal cavity are treated, with chemotherapy applied directly in the abdominal cavity, without the proper tools for a physician to follow up on the treatment. This in combination with the current uncertainties with regards to the optimal amount of drug to use and the optimal treatment duration make that, in our opinion, much room is left for improvement of the current implemented ...