Researcher
Steven Goossens
- Keywords:In vitro models, cell biology, in vivo animal models, mouse model, translational research, leukemia, Metastasis
- Disciplines:Hematology, Cancer biology, Cancer therapy
Affiliations
- Department of Diagnostic Sciences (Department)
Member
From1 Oct 2019 → Today - Department of Biomolecular Medicine (Department)
Member
From1 Oct 2018 → 30 Sep 2019 - Department of Pediatrics and medical genetics (Department)
Member
From1 Oct 2016 → 30 Sep 2018 - Department of Biomedical molecular biology (Department)
Member
From1 Feb 2000 → 30 Sep 2019
Infrastructure
1 - 1 of 1
- Patient Derived Xenograft Platform Ghent (Consortium coordinator)
Projects
1 - 10 of 22
- Facility : Patiënt-afgeleide xenograft modellen – UGent;From1 Feb 2024 → TodayFunding: BOF - research organisations
- Establishing safety and efficacy of an improved Asparaginase in dog models: final preparation for Phase I clinical trialFrom1 Jan 2024 → TodayFunding: Nonprofit institution or equivalents
- Towards clinical testing of novel stabilized less toxic asparaginases for the treatment of acute lymphoblastic leukemiaFrom20 Dec 2023 → TodayFunding: IOF - technology validation in lab
- Targeting the amino acid stress response (AAR) pathway to treat triple negative breast cancersFrom1 Oct 2023 → TodayFunding: Nonprofit institution or equivalents
- Towards clinical testing of improved, less toxic and less immunogenic, L-asparaginase preparations for the treatment of acute lymphoblastic leukemiaFrom1 Oct 2023 → TodayFunding: BOF - postdoctoral mandates
- Oncogenic Role of SOX11 in T-cell acute lymphoblastic leukemiaFrom1 Jan 2023 → TodayFunding: Foundations, funds and other with scientific goal
- Preclinical validation of a less toxic variant for paediatric leukemiaFrom1 Oct 2022 → 30 Sep 2023Funding: Nonprofit institution or equivalents
- A patient derived xenograft (PDX) platform for in vivo evaluation of novel anticancer therapiesFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Replication fork protector dependency factors: novel targets for combination treatment and immunomodulation in neuroblastoma (REINFORCE)From1 Jan 2022 → TodayFunding: BOF - projects
- Targeting MEF2C in immature acute leukemiasFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
Publications
1 - 10 of 17
- The epithelial-mesenchymal plasticity landscape: principles of design and mechanisms of regulation(2023)
Authors: Jef Haerinck, Steven Goossens, Geert Berx
Pages: 590 - 609 - In vivo stabilization of a less toxic asparaginase variant leads to a durable antitumor response in acute leukemia(2023)
Authors: Maaike Van Trimpont, Amanda M. Schalk, Yanti De Visser, Hien Anh Nguyen, Lindy Reunes, Katrien Vandemeulebroecke, Evelien Peeters, Ying Su, Hyun Lee, Philip L. Lorenzi, et al.
Pages: 409 - 419 - Mutations in the histone methyltransferase Ezh2 drive context-dependent leukemia in Xenopus tropicalis(2023)
Authors: Dieter Tulkens, Marthe Boelens, Thomas Naert, Marjolein Carron, Suzan Demuynck, Sylviane Dewaele, Gert Van Isterdael, David Creytens, Tim Pieters, Steven Goossens, et al.
Pages: 2404 - 2413 - Novel insights on the use of L-asparaginase as an efficient and safe anti-cancer therapy(2022)
Authors: Maaike Van Trimpont, Evelien Peeters, Yanti De Visser, Amanda M. Schalk, Veerle Mondelaers, Barbara De Moerloose, Arnon Lavie, Tim Lammens, Steven Goossens, Pieter Van Vlierberghe
- RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition(2022)
Authors: Carolina de Carvalho Nunes, Lisa Depestel, Liselot Mus, Kaylee M. Keller, Louis Delhaye, Amber Louwagie, Muhammad Rishfi, Alex Whale, Neesha Kara, Simon R. Andrews, et al.
- MEF2C opposes Notch in lymphoid lineage decision and drives leukemia in the thymus(2022)
Authors: Kirsten Canté-Barrett, Mariska T. Meijer, Valentina Cordo, Rico Hagelaar, Wentao Yang, Jiyang Yu, Willem K. Smits, Marloes E. Nulle, Joris P. Jansen, Rob Pieters, et al.
- Pancreas morphogenesis and homeostasis depends on tightly regulated Zeb1 levels in epithelial cells(2021)
Authors: Maria Lasierra Losada, Melissa Pauler, Niels Vandamme, Steven Goossens, Geert Berx, Moritz Leppkes, Harald Schuhwerk, Simone Brabletz, Thomas Brabletz, Marc P. Stemmler
- The spleen as a sanctuary site for residual leukemic cells following ABT-199 monotherapy in ETP-ALL(2021)
Authors: Alessandra Di Grande, Sofie Peirs, Paul D. Donovan, Maaike Van Trimpont, Julie Morscio, Béatrice Lintermans, Lindy Reunes, Niels Vandamme, Steven Goossens, Hien Anh Nguyen, et al.
Pages: 1963 - 1976 - Interplay between the EMT transcription factors ZEB1 and ZEB2 regulates hematopoietic stem and progenitor cell differentiation and hematopoietic lineage fidelity(2021)
Authors: Jueqiong Wang, Carlos Farkas, Aissa Benyoucef, Catherine Carmichael, Katharina Haigh, Nick Wong, Danny Huylebroeck, Marc P. Stemmler, Simone Brabletz, Thomas Brabletz, et al.
- Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma(2020)
Authors: Renate De Smedt, Julie Morscio, Lindy Reunes, Juliette Roels, Valentina Bardelli, Béatrice Lintermans, Wouter Van Loocke, Afonso Almeida, Laurence C. Cheung, Rishi S. Kotecha, et al.
Pages: 1685 - 1695