The role of organelle contact sites in Parkinson’s disease-associated α-synuclein toxicity: insights from a yeast model KU Leuven
This PhD project aimed to identify novel players involved in α-syn toxicity, with a particular focus on those involved in inter-organelle communication. The general goal was to elucidate the molecular mechanisms that underlie α-syn toxicity and uncover the role of MCSs in this process. The first experimental part of this study was dedicated to identifying MCS deletion mutants involved in mediating α-syn toxicity. In order to achieve this, we ...