A pipeline for phage lysins targeting multidrug-resistant Staphylococcus pseudintermedius in canine pyoderma and bacterial otitis externa Ghent University
Phage lysins are enzymes produced by bacterial viruses (phages) at the end of their replication cycle. These enzymes degrade the peptidoglycan layer, resulting in lysis of the infected cell and release of the newly matured phage particles. Recombinantly produced and purified phage lysins constitute a novel class of enzyme-based antibiotics. These are currently developed for human therapy with the first clinical trial showing superiority ...