Projects
Delivery of CRISPR-Cas9 mRNA-based therapy into the inner ear by lipid nanoparticles: Cure deafness by disrupting mutant COCH expression in a humanized DFNA9 mouse model. University of Antwerp
Development of a CRISPR-nuclease gene therapy to cure deafness in DFNA9 patients. University of Antwerp
Towards a cure for deafness in DFNA9: loading lipid nanoparticles with CRISPR-Cas9 to safely target dominant-negative mutations in the COCH gene in vitro and in vivo. University of Antwerp
Company DNA: the road to human-centered organisations VIVES
Sabbatical Enrico Carlon: Dynamics of DNA/ Proteins interactions KU Leuven
An interesting and very active field of research within physics is the study of biological systems. Advanced experimental techniques can investigate and monitor dynamic processes, both in living cells and in vitro. The measurements have a very high time and length scale resolution. With modern methods it is possible to quantify time scales, forces and energies involved in life processes. These experiments have strongly linked the methodology ...
Control of the DNA stress cell checkpoint in plants / DNA stress control in Arabidopsis thaliana Ghent University
Recently, the WEE1 gene of Arabidopsis thaliana was identified as a crucial cell cycle regulator. Upon DNA stress, induced WEE1 expression results into a cell cycle arrest, by which damaged DNA can be repaired. We wish to identify the signal transduction pathway inducing WEE1. Secondarily, we aim to identify other genes that contribute to the activation of the DNA stress checkpoint, and to combine all biological data into a mathematical ...
Concept development of stochastic impedance and its lab-on-chip application to monitor DNA hybridization Hasselt University
Universal, cost-effective and hypersensitive open-source technology platform for liquid biopsy based on methylome profiling of circulating DNA. Ghent University
The methylation pattern of DNA released by dying cells in body-fluids is specific to each (pathological) cell type. Therefore, it constitutes a universal source of diagnostic information. Together, we are building a molecular-biological methylation-profiling technology, innovating for higher-sensitivity detection of low-abundance methylation patterns. Simultaneously, we maintain a feasible cost for clinical use, and we test the technology in ...