Researcher
Nico Callewaert
- Keywords (Ghent University):medical biotechnology, protein engineering
- Disciplines (Flanders Institute for Biotechnology):Analytical biochemistry, Cell death and senescence, Analysis of next-generation sequence data, General diagnostics
- Disciplines (Ghent University):Infectious diseases, Proteins, Systems biology not elsewhere classified, Cell, tissue and organ engineering, Protein diagnostics, Medical biotechnology diagnostics, Medical molecular engineering of nucleic acids and proteins, Molecular biophysics, Microbiology not elsewhere classified, Immunology not elsewhere classified
Affiliations
- Department of Biomolecular Medicine (Department)
Member
From1 Oct 2018 → Today - VIB-UGent Center for Medical Biotechnology (Research Center)
Responsible
From1 Jan 2017 → Today - Callewaert Lab (Research group)
Responsible
From1 Jan 2017 → Today - Department of Biochemistry (Department)
Member
From1 May 2014 → 30 Sep 2018 - Department of Biochemistry and microbiology (Department)
Member
From1 Oct 2006 → Today - Department of Biomedical molecular biology (Department)
Member
From1 Oct 1998 → 30 Apr 2009
Projects
1 - 10 of 58
- Arming therapeutic CAR-T cells with glyco-engineered suppressors of tumor-infiltrating regulatory T cellsFrom1 Jan 2023 → Today
- Flow imaging microscope for advanced analysis of biopharmaceuticals and biological samplesFrom15 Dec 2022 → TodayFunding: BOF - scientific equipment program
- Synthetic glyco-biotechnology: arming therapeutic CAR-T cells with glyco-engineered suppressors of tumor-infiltrating regulatory T cells.From1 Nov 2022 → TodayFunding: FWO Strategic Basic Research Grant
- Validation and implementation of a prognostic biomarker of early graft failure after liver transplantation (GlycoTransplantTest)From1 Oct 2022 → TodayFunding: FWO Applied Biomedical Research (TBM)
- cfRRBS: translation of technological advances in methylation profiling of circulating free DNA for minimally invasive classification and relapse detection of high-grade lymphomaFrom1 Jan 2022 → TodayFunding: Nonprofit institution or equivalents
- Development of a minimally-invasive test for accurate diagnosis of Cancer of Unknown Primary (CUP) using DNA methylation profilingFrom1 Oct 2021 → TodayFunding: BOF - projects
- Investigation of Nanobody-based LYsosome TArgeting Chimeras (nanoLYTACs): a novel concept in therapy of cancer and viral infection.From1 Jan 2021 → TodayFunding: FWO research project
- A MALDI-8020 mass spectrometer for peptide and protein analysis.From1 Dec 2020 → 30 Nov 2022Funding: BOF - scientific equipment program
- Understanding, optimizing and expanding target space of yeast-secreted, edible antibodies.From1 Nov 2020 → TodayFunding: FWO Strategic Basic Research Grant
- Nanobody-based LYsosome TArgeting Chimeras (nanoLYTACs): development of a novel platform for lysosome-mediated targeted protein degradationFrom1 Nov 2020 → TodayFunding: FWO Strategic Basic Research Grant
Publications
1 - 10 of 134
- The 3-O sulfation of heparan sulfate proteoglycans contributes to the cellular internalization of tau aggregates(2022)
Authors: Andreia Sofia da Costa de Monica Ferreira, Ines Royaux, Jian Liu, Zhangjie Wang, Guowei Su, Diederik Moechars, Nico Callewaert, Louis De Muynck
- Yeast-produced fructosamine-3-kinase retains mobility after ex vivo intravitreal injection in human and bovine eyes as determined by Fluorescence Correlation Spectroscopy(2022)
Authors: An-Katrien Minnaert, Loes van Schie, Hendrik Grootaert, Jonas Himpe, Simon Devos, Wannes Weyts, Herlinde De Keersmaecker, Kevin Braeckmans, Elisabeth Van Aken, Joris Delanghe, et al.
- Validation of a glycomics-based test associated with risk of HCC development in cirrhosis(2022)Volume: 77
Authors: Xavier Verhelst, Leander Meuris, Roos Colman, Annelies Van Hecke, Anja Geerts, Nico Callewaert, Hans Van Vlierberghe
Pages: S913 - S913 - GENType : all-in-one preimplantation genetic testing by pedigree haplotyping and copy number profiling suitable for third-party reproduction(2022)
Authors: Lisa De Witte, Lennart Raman, Machteld Baetens, Andries De Koker, Nico Callewaert, Sofie Symoens, Kelly Tilleman, Frauke Vanden Meerschaut, Annelies Dheedene, Björn Menten
Pages: 1678 - 1691 - GlyConnect-Ugi : site-selective, multi-component glycoprotein conjugations through GlycoDelete expressed glycans(2022)
Authors: Karel Thooft, Wander Van Breedam, Francis Santens, Elise Wyseure, Sandrine Vanmarcke, Simon Devos, Nico Callewaert, Annemieke Madder
Pages: 464 - 471 - Pretransplant alterations in serum protein glycosylation are associated to risk of hcc recurrence after liver transplantation and provide a potential prognostic biomarker : a proof-of-concept study(2022)Volume: 106
Authors: Xavier Verhelst, Luis Abreu De Carvalho, Helena Degroote, Leander Meuris, Frederik Berrevoet, Nico Callewaert, Hans Van Vlierberghe
Pages: 20 - 20 - Pretransplant changes in serum protein glycosylation relate to risk of HCC recurrence after liver transplantation and provide a potential prognostic biomarker : a proof-of-concept study(2022)Volume: 77
Authors: Xavier Verhelst, Anja Geerts, Luis Abreu De Carvalho, Helena Degroote, Leander Meuris, Frederik Berrevoet, Nico Callewaert, Hans Van Vlierberghe
Pages: S768 - S768 - A potential role for fructosamine-3-kinase in cataract treatment(2021)
Authors: Sander De Bruyne, Loes van Schie, Jonas Himpe, Filip De Somer, Inge Everaert, Wim Derave, Caroline Van den Broecke, Manon Huizing, Nezahat Bostan, Marijn Speeckaert, et al.
- Engineering of yeast glycoprotein expression(2021)
Authors: Charlot De Wachter, Linde Van Landuyt, Nico Callewaert, Erdmann Rapp, Udo Reichl
Pages: 93 - 135 - T cell engaging immunotherapies, highlighting chimeric antigen receptor (CAR) T cell therapy(2021)
Authors: Elien De Bousser, Nico Callewaert, Nele Festjens
Patents
1 - 10 of 10
- Improved aminopeptidases for single molecule peptide sequencing (Inventor)
- GLYCOSYLATED SINGLE CHAIN IMMUNOGLOBULIN DOMAINS (Inventor)
- Cells producing Fc containing molecules having altered glycosylation patterns and methods and use thereof (Inventor)
- Cells producing glycoproteins having altered N- and O-glycosylation patterns and methods and use (Inventor)
- Means and methods for generating complex glycans derived from fungal engineered hosts (Inventor)
- Means and methods for single molecule peptide sequencing (Inventor)
- Means and methods for amplifying nucleotide sequences (Inventor)
- Means and methods for amplifying nucleotide sequences (Inventor)
- Means and methods for single molecule peptide sequencing (Inventor)
- Genetically engineered eukaryotic cells producing sialylated glycoproteins (Inventor)