Targeting activated fibroblasts as novel therapeutic avenue for inflammatory bowel disease KU Leuven
Inflammatory bowel disease (IBD) is a chronic recurrent inflammatory disorder of the gastrointestinal tract, leading in the majority of patients to remodelling of the gut wall which lies at the basis of complications such as fistulas/abscesses, fibrosis and strictures. Our preliminary data indicate that crosstalk between fibroblasts and myeloid cells promotes chronic inflammation during IBD. These fibroblasts have a hyperactivated phenotype ...