Researcher
Savvas Savvides
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Adaptive immunology, Bacteriology
- Disciplines (Ghent University):Molecular biophysics, Biochemistry and metabolism not elsewhere classified, Carbohydrates, Analytical biochemistry, Inorganic elements and compounds, Intracellular compartments and transport, Nucleic acids, Lipids, Other organic elements and compounds, Membrane structure and transport, Cytoskeleton
- See also: Savvas Savvides (Flanders Institute for Biotechnology)
Affiliations
- Savvides Lab (Research group)
Responsible
From1 Jan 2017 → Today - Department of Biochemistry and microbiology (Department)
Member
From1 Jan 2004 → Today
Projects
1 - 10 of 46
- 'Take 1' on TAOK2: structural insights into TAOK2 and its complexes with TRIM4 and viral dsRNAFrom1 Nov 2023 → TodayFunding: FWO fellowships
- Structural and functional insights into the role of Themis:SHP-1 complexes in inflammationFrom1 Oct 2022 → TodayFunding: FWO senior postdoctoral fellowship
- An integrated approach to unravel eosinophil function in chronic eosinophilic disordersFrom1 Jan 2022 → TodayFunding: FWO EOS
- Rational design of biologics for therapeutic development (FoldCo)From1 Oct 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
- Targeting transcription factor addiction in acute leukemia (TaTFAL)From1 Oct 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
- Understanding the immunological basis of persistent airway obstruction in asthmaFrom1 Jan 2021 → TodayFunding: BOF - Methusalem
- Development of small-molecule inhibitors targeting pro-inflammatory and pruritogenic IL-31From15 Jul 2020 → 30 Sep 2022Funding: IOF - technology concept exploration
- Unraveling the structural and functional roles of THEMIS proteins in T cell and B cell development and inflammationFrom1 Jan 2020 → 31 Dec 2023Funding: FWO research project (including WEAVE projects)
- Engineering and study of peptide-based hydrogels for the sustained release of therapeutic proteins.From1 Nov 2019 → 28 Oct 2023Funding: FWO Strategic Basic Research Grant
- Structural and functional insights into the role of Themis1 and Themis2 in inflammation.From1 Oct 2019 → 30 Sep 2022Funding: FWO junior postdoctoral fellowship
Publications
1 - 10 of 102
- Ym1 protein crystals promote type 2 immunity(2024)
Authors: Ines Heyndrickx, Kim Deswarte, Kenneth Verstraete, Koen Verschueren, Ursula Smole, Helena Catharine Aegerter, Ann Dansercoer, Hamida Hammad, Savvas Savvides, Bart Lambrecht
- Improving de novo protein binder design with deep learning(2023)
Authors: Nathaniel R. Bennett, Brian Coventry, Inna Goreshnik, Buwei Huang, Aza Allen, Dionne Vafeados, Ying Po Peng, Justas Dauparas, Minkyung Baek, Lance Stewart, et al.
- Pore-forming proteins as drivers of membrane permeabilization in cell death pathways(2023)
Authors: Peter Vandenabeele, Geert Bultynck, Savvas Savvides
Pages: 312 - 333 - EGOC inhibits TOROID polymerization by structurally activating TORC1(2023)
Authors: Manoël Prouteau, Clélia Bourgoint, Jan Félix, Lenny Bonadei, Yashar Sadian, Caroline Gabus, Savvas Savvides, Irina Gutsche, Ambroise Desfosses, Robbie Loewith
Pages: 273 - 285 - Unexpected complexity of the ammonia monooxygenase in archaea(2023)
Authors: Logan H. Hodgskiss, Michael Melcher, Melina Kerou, Weiqiang Chen, Rafael I. Ponce-Toledo, Savvas Savvides, Stefanie Wienkoop, Markus Hartl, Christa Schleper
Pages: 588 - 599 - Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice(2023)
Authors: Karel Van Damme, Pieter Hertens, Arne Martens, Elisabeth Gilis, Dario Priem, Inge Bruggeman, Amelie Fossoul, Jozefien Declercq, Helena Catharine Aegerter, Andy Wullaert, et al.
- Point mutation I634A in the glucocorticoid receptor causes embryonic lethality by reduced ligand binding(2022)
Authors: Steven Timmermans, Nicolette J.D. Verhoog, Kelly Van Looveren, Sylviane Dewaele, Tino Hochepied, Melanie Eggermont, Barbara Gilbert, Anne Boerema-de Munck, Tineke Vanderhaeghen, Joke Vanden Berghe, et al.
- The STE20 kinase TAOK3 controls the development of house dust mite-induced asthma in mice(2022)
Authors: Bastiaan Maes, Ursula Smole, Matthias Vanderkerken, Kim Deswarte, Justine Van Moorleghem, Karl Vergote, Manon Vanheerswynghels, Caroline De Wolf, Sofie De Prijck, Nincy Debeuf, et al.
Pages: 1413 - 1427.e2 - The Charcot-Leyden crystal protein Galectin-10 is not a major determinant of human regulatory T-cell function(2022)
Authors: Rebeca Arroyo-Hornero, Ibrahim Hamad, Beatriz Corte-Real, Katrien Staes, Bas van Der Woning, Kenneth Verstraete, Savvas Savvides
Pages: 2818 - 2821 - Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27(2022)
Authors: Katarzyna Skladanowska, Yehudi Bloch, Jamie Strand, Kerry F. White, Jing Hua, Daniel Aldridge, Martin Welin, Derek T. Logan, Arne Soete, Romain Merceron, et al.
Patents
1 - 6 of 6
- GALECTIN-10 ANTIBODIES (Inventor)
- NOVEL TSLP INHIBITORS (Inventor)
- GALECTIN-10 ANTIBODIES (Inventor)
- CRYSTAL STRUCTURE OF ATP CITRATE LYASE AND USES THEREOF (Inventor)
- GALECTIN-10 ANTIBODIES (Inventor)
- NOVEL TSLP INHIBITORS (Inventor)