Macrocycle-mediated in vivo 'gluing' of T cells and cancer cells to improve T cell killing Ghent University
T lymphocytes play a critical role in tumor immunity by recognizing and subsequent killing of cancer
cells. Cold tumors that have limited or no T cell infiltrate, can be treated through infusion of ex vivo
engineered T cells. However, in the tumor microenvironment, T cells face a series of physical and
immune-biological barriers. Hence, we hypothesize that a window of opportunity exists for
strategies that enhance the ...