Projects
Investigating the biomarker potential and pathological role of extracellular vesicles in Parkinson’s disease. Ghent University
Accumulating evidence indicates that extracellular vesicles (EVs) represent a highly interesting biomarker source, both as a total population and after enriching for specific subpopulations. Indeed, neuronal- derived EVs (nEVs) separated from peripheral sources provide a snapshot of ongoing pathological changes in the brain whereas bacterial EVs (bEVs) have shown to reflect microbial dysbiosis. Interestingly, both neuronal changes and ...
A mucin mRNA isoform-based biomarker assay to improve treatment response in patients with inflammatory bowel diseases. University of Antwerp
Investigating the biomarker potential and pathological role of neuronal- and bacterial- derived extracellular vesicles in Parkinson’s disease. Ghent University
Accumulating evidence indicates that extracellular vesicles (EVs) represent a highly interesting biomarker source. Indeed, neuronal-derived EVs (nEVs) separated from peripheral sources provide a snapshot of ongoing pathological changes in the brain whereas bacterial EVs (bEVs) have shown to reflect microbial dysbiosis. Interestingly, both neuronal changes and microbial dysbiosis are evident in Parkinson’s disease (PD) patients. Additionally, ...
A mucin isoform-based biomarker assay to improve follow-up and treatment of inflammatory bowel diseases (IBD) and gastrointestinal (GI) cancers. University of Antwerp
Validation of a protein biomarker panel in exhaled breath condensate. University of Antwerp
Validation of a biomarker panel for the diagnosis of malignant pleural mesothelioma. University of Antwerp
Validating the application of a first-in-class human serum-functional immunodynamic status (sFIS) assay as bona fide immuno-oncology biomarker KU Leuven
Development of tools and methods for the evaluation of FAP as a predictive/prognostic biomarker in cancer. University of Antwerp
Blood groups as biomarker to Optimize Odds of response to anti-PD-1 Drugs (BLOOD trial) Ghent University
Dampening of the immune response is coordinated by the expression of immune checkpoint receptors to
avoid autoimmunity and the deleterious effects of an excessive inflammatory response. It is well established that multiple
cell types within the tumor microenvironment hijack these checkpoint signaling pathways to restrain T cell activation and
as such an effective ...