Projects
Implementing clinical bacteriology in low-resource settings: a new perspective on old methods KU Leuven
Antimicrobial resistance is a global public health threat. Low-resource settings are disproportionally burdened due to high incidence of infectious diseases and high rates of resistance, although representative data on antimicrobial resistance rates in low-resource settings are scarce. Moreover, antimicrobial resistance is aggravated in these settings by a lack of diagnostic tools to correctly diagnose bacterial infections, leading to ...
Old school bacteriology revisited: need for in-depth knowledge on bacterial growth to tune diagnosis of bloodstream infections for use in low resource settings Institute of Tropical Medicine
Pilot clinical bacteriology in the EVD care response to detect intercurring bloodstream infections and inform about appropriate antibiotic treatment Institute of Tropical Medicine
ENERGISE: nExt-geNEration Rapid phenotypic bacterioloGy dIagnostics for low-reSource and rEmote settings Ghent University
Antimicrobial resistance (AMR) is a major global threat, particularly in low-resource settings (LRS)
like sub-Saharan Africa. Alas, diagnosing bacterial infections and preventing AMR is hampered by a
lack of feasible diagnostic tests, like blood culture diagnostics. Current methods are exceedingly
complex to implement in the settings where the crisis of AMR is already most acute. To address this,
a partnership between ...
Data-based modeling of recovery from mastitis in dairy cows KU Leuven
The prevention, detection and treatment of mastitis forms the basis for the contemporary udder-health management. After detection and startup of treatment, recovery; being the suppression of the causal pathogen (bacteriological healing), the disappearance of clinical symptoms and the regeneration of the udder tissue (clinical healing) isn't objetively monitored. Due to lack of information about this recovery, it is impossible for the dairy ...
Improved udder-health by monitoring recovery in mastitis KU Leuven
The prevention, detection and treatment of mastitis forms the basis for the contemporary udder-health management. After detection and startup of treatment, recovery; being the suppression of the causal pathogen (bacteriological healing), the disappearance of clinical symptoms and the regeneration of the udder tissue (clinical healing) isn't objetively monitored. Due to lack of information about this recovery, it is impossible for the dairy ...
A better udder health by monitoring recovery in mastitis Ghent University
The prevention, detection and treatment of mastitis form the basis for contemporary udder health management. After detection and initiation of treatment, the recovery, being the suppression of the causal pathogen (bacteriological healing), the disappearance of clinical symptoms and the regeneration of the udder tissue (clinical healing), is almost objec- tively monitored. Due to lack of information about this recovery, it is impossible for ...
Evaluation of the preprotein translocation motor SecA as a target for the development of novel antibiotics KU Leuven
The fight against bacterial infections is one of the major concerns in modern medicine due to the rapid rise of antibiotic-resistant bacteria. Therefore, there is an urgent need for new antibacterials – preferably directed against alternative bacterial targets – to combat hardly treatable infections caused by these resistant bacteria. One such potential target is the preprotein translocation motor SecA. SecA is a peripheral membrane ATPase ...
Structural dynamics basis of function in the SecB chaperone KU Leuven
How chaperones act on their clients remains a major universal unresolved issue and modulate folding pathways in ways that are still debatable. Some of them are proposed to act as 'holdases' that tightly bind to polypeptides and others like true 'foldases' providing active contribution to the folding process. In the secretory pathway the role of chaperones is critical as secretory polypeptides need to remain non-folded for several seconds in ...