Unravelling the role of BK polyomavirus genetic variants in viral pathogenicity and clearance in kidney transplant recipients KU Leuven
BK polyomavirus is the first human polyomavirus discovered in the early 70s in a kidney transplant patient. The immunosuppression state of the patient can lead to reactivation of the virus, leading in 30% of the case to graft loss. Up to now, no protocol for the management of BKPyV associated nephropathy has been established. The combination of immunosuppressive drug tapering and cidofovir (an anti-DNA virus agent) permits in many cases to ...