Projects
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Mitochondrial abnormalities in critical illness: role in organ failure and mortality, underlying mechanisms and therapeutic perspectives. KU Leuven
Critically ill patients have a high risk of multiple organ failure and death. A disturbed cellular energy metabolism likely contributes to the organ system dysfunction, which is in fact the most common cause of death in intensive care units. Previous studies of our group showed that strict glycemic control with intensive insulin therapy reduces the risk of organ failure and death and that protection of the mitochondria, that are responsible for ...
Optimal point-to-point motion control of machine tools. KU Leuven
Production Engineering, Machine Design and Automation (PMA) Section, ESAT - STADIUS, Stadius Centre for Dynamical Systems, Signal Processing and Data Analytics
The goal of this project is to develop efficient methods to optimize the point-to-point motion of machine tools. Machine tools are mechatronic systems that are generally described by either a linear time-invariant (LTI) model or a linear parameter varying (LPV) model. The proposed methods are based on the following approaches: Optimize motion trajectories and combine them with classical cascade or robust linear time-invariant (LTI) controllers. ...
Advanced resource planning in the healthcare sector: impact of time-varying demand. KU Leuven
The objective of the proposed project is to develop a framework for aggregate resource planning, in view of its specific application in the healthcare industry. The proposal incorporates fundamental research aimed at improving patient flow in hospitals, through an advanced approach for capacity planning of resources, which explicitly takes into account the time-varying aspect of the demand for healthcare services. We intend to make fundamental ...
PhageBiotics. KU Leuven
The PhageBiotics Research Community Bacteriophage therapy is currently being evaluated as an alternative/complementary antibacterial treatment. The use of specific viruses against antibiotic resistant bacteria (like Staphylococcus aureus and Pseudomonas aeruginosa) is currently being studied from both fundamental and applied perspectives by the partners involved. This cooperation will help streamline their research in developing bacteriophage ...
Use of Tissue Doppler Imaging (TDI) and 2D Speckle Tracking (ST) to evaluate left ventricular function in horses Ghent University
Uding TDI and ST, left ventricular function in healthy horses is quantified and the accuracy of the measurements analyzed. Subsequently, the effect of a pharmacological stimulation or depression of ventricular function, a ventricular premature beat and the presence of mitral regurgitation on the TDI and ST parameters is studied.
Predictive data mining: new techniques and applications. KU Leuven
Operations Research and Statistics Research Group (ORSTAT) (main work address Leuven), Information Systems Engineering Research Group (LIRIS) (main work address Leuven)
In this age of computerized data processing, more and more structured data becomes available. This is mainly driven by the automation of processes, and innovative storage technologies. Although useful and valuable knowledge is hidden in these vast amounts of data, it is typically hidden. Data mining entails the automatic inferring of patterns and knowledge from this data in order to come to a better decision making process. The need for proper, ...
Atrial septal defect: evaluation of the therapeutic approach in Belgium through a national database of congenital heart disease. KU Leuven
Atrial septal defect (ASD) represents approximately 10% of all congenital heart diseases (CHD) and is the third most common form of congenital heart defects. The incidence of CHD in Belgium is 1%, with ASD accounting for 25% of the cases. (Data from the database of CHD UZ Leuven.) A substantial shunt through the defect from the left to the rightatrium, causing a progressive volume overload of the right heart and pulmonary circulation, may lead ...
Biofouling in submerged membrane bioreactors. University of Antwerp
In this research project the complex causes and mechanisms of fouling in membrane bioreactors will be investigated. For this purpose a new fouling measurement method will be developed which allows to distinguish between reversible (can be removed by mechanical cleaning) and irreversible fouling (can only be removed by chemical cleaning). The system will be used to detect relationships between operational parameters and (ir)reversible fouling. ...
Iterative model and control learning for highly nonlinear systems. KU Leuven
The aim of this project is to develop methods to design iterative learning controllers (ILC) for highly non-linear systems. The innovative elements of this project are: Simultaneous iterative learning of controller AND non-linear model Identification of approximating non-linear models in every iteration Experimental validation of these methods