Xeno-nucleic acid polymerases by directed evolution. KU Leuven
Artificial or xeno nucleic acids (XNAs) present an alternative to natural genetic polymers by expanding chemical diversity and improving chemical and biological stability, with potential applications in, for example, therapeutics. XNA differs from its natural counterparts by modifications applied to the nucleobases, sugar-phosphate backbone, nucleotide leaving group, or a combination of these. In the long run, XNA could form the basis of an ...