Inhibition of basophil and mast cell activation by CD300a: is there a role for apoptotic signals? University of Antwerp
Despite the high efficacy of allergen-specific immunotherapy, little is known about the mechanisms leading to suppression of basophils and mast cells, which are responsible for the allergic reaction. Therefore, we will assess whether CD300a might be involved in succesfull allergen-specific immunotherapy. It is anticipated that immunotherapy might alter the basophilic and mast cellexpression of this receptor, thereby rendering these cells less ...