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Role of inhibitory receptors in piecemeal and anaphylactic degranulation of basophils and mast cells.
In this project we will continue and extend our explorations of activation markers, inhibitory receptors, signalling molecules and release of mediators such as histamine that was initiated in FWO project 1800609N. Our purpose is to further explore and disentangle the mechanisms that regulate piecemeal and anaphylactic degranulation of basophils and mast cells. In addition we will explore the mechanisms that could account for temporarily (allergenspecific) hypo- and unresponsiveness of both cells.
Date:1 Oct 2013 → 30 Sep 2018
Keywords:MAST CELLS, BASOPHILS, IMMUNOTHERAPY