Structural Characterization of Aminoacyl-tRNA Synthetase Inhibitors as Antibiotics and Tools for Enzyme Mechanistic Studies KU Leuven
The alarming development and spread of resistance to our current stock of antibiotics is recognized as one of the major threats to human health in the 21st century. To combat this emerging crisis, efforts to develop drugs active against novel protein targets are of great importance. Aminoacyl-tRNA synthetases (aaRSs) catalyzing the formation of aminoacyl-tRNA, are clinically validated antibacterial targets. Using the non-hydrolysable ...