Optimization of an innovative approach to eliminate CD70-positive cancer-associated fibroblasts to improve first-line chemotherapy in advanced colorectal cancer. University of Antwerp
Cancer-associated fibroblasts (CAFs) provide a physical barrier for the delivery of systemic therapy to the tumor, making it an attractive target to combine with conventional treatment. Clinically addressing CAFs has been challenging due to its heterogeneous nature with both cancer-promoting and -restraining features. We have recently identified a distinct subset of CAFs in colorectal cancer specimens, marked by the expression of immune ...