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Researcher
Steven De Jonghe
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 May 2017 → Today - Medicinal Chemistry (Rega Institute) (Division)
Member
From18 Feb 2002 → 30 Apr 2017
Projects
1 - 10 of 18
- Synthesis of agonists for the C-C chemokine receptor type 5 (CCR5), derived from a substituted 4-aminopiperidinyl lead structureFrom1 Jan 2023 → TodayFunding: BOF - doctoral mandates
- Optimisation of a triterpene lead compound for the development of pan-anticoronavirus drugs targeting nsp15From3 Jan 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Synthesis and structure-activity relationship studies of CCR8 agonists as a novel treatment option for autoimmune diseasesFrom27 Oct 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- The synthesis of novel CXCR4 antagonists for use in oncology and molecular imagingFrom1 Oct 2020 → 30 Sep 2021Funding: BOF - postdoctoral mandates
- An NMR facility tailored for biomedical researchFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Synthesis of nucleoside analogues as antiviral and antibacterial agentsFrom10 Feb 2020 → 10 Feb 2024Funding: Own budget, for example: patrimony, inscription fees, gifts
- Development and application of NanoBRET-based technology: Unravelling signalling bias at the human chemokine receptors CXCR1 and CXCR2From3 Sep 2019 → 3 Sep 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Synthesis of CXCR2 and CCR7 chemokine receptor antagonists targeting a conserved intracellular binding siteFrom3 Oct 2018 → 10 Jan 2023Funding: BOF - doctoral mandates
- Establishment of in vitro assays for the discovery of GPCR small molecule ligandsFrom30 May 2018 → 30 May 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- IN SEARCH FOR SUGAR, BASE OR PHOSPHATE MODIFIED NUCLEOSIDES ACTIVE AGAINST RNA VIRUSESFrom30 Nov 2017 → 7 Mar 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
1 - 10 of 129
- Identification of novel human CC chemokine receptor 8 (CCR8) antagonists via the synthesis of naphthalene amide and sulfonamide isosteres.(2024)
Authors: Dominique Schols, Steven De Jonghe
Pages: 107181 - Design, synthesis, and molecular modeling studies of novel 2-quinolone-1,2,3-triazole-α-aminophosphonates hybrids as dual antiviral and antibacterial agents.(2024)
Authors: Johan Neyts, Dirk Jochmans, Steven De Jonghe
Pages: 116235 - Synthesis of benzo[d]isothiazoles: an update(2024)
Authors: Yulia Ivanova, Steven De Jonghe, Wim Dehaen
- Development of a cellular model to study CCR8 signaling in tumor-infiltrating regulatory T cells(2024)
Authors: Libao Liu, Susan Schlenner, Steven De Jonghe, Dominique Schols, Tom Van Loy
- A new alkaloid from Pancratium maritimum - Structure elucidation using computer-assisted structure elucidation (CASE) and evaluation of cytotoxicity and anti-SARS-CoV-2 activity(2023)
Authors: Steven De Jonghe, Johan Neyts, Christophe Pannecouque
Pages: 1 - 7 - Synthesis and Biological Evaluation of 2-Substituted Quinazolin-4(3H)-Ones with Antiproliferative Activities(2023)
Authors: Dominique Schols, Steven De Jonghe
- Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.(2023)
Authors: Steven De Jonghe, Kim Donckers, Dirk Jochmans, Johan Neyts
Pages: eabo7201 - Synthesis of mizoribine prodrugs and their in vivo evaluation as immunosuppressive agents(2023)
Authors: Ling-Jie Gao, Steven De Jonghe, Mark Waer, Piet Herdewyn
- Photo-induced scandium-catalyzed biomimetic skeleton conversion of lathyrane to naturally rare eupholathone Euphorbia diterpenes(2023)
Authors: Steven De Jonghe
Pages: 12290 - 12293 - Photo-induced scandium-catalyzed biomimetic skeleton conversion of lathyrane to naturally rare eupholathone Euphorbia diterpenes(2023)
Authors: Steven De Jonghe, Dominique Schols
Pages: 12290 - 12293
Patents
1 - 10 of 10
- Isoquinoline and pyridine based cxcr4 antagonists (Inventor)
- Prodrugs of nucleoside phosphonates (Inventor)
- Novel prodrugs of nucleoside phosphonates (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Antiviral activity of bicyclic heterocycles (Inventor)
- Antiviral compounds, a process for their preparation, and their use for treating viral infections (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Purine analogues and their use as immunosuppressive agents (Inventor)
- Novel prodrugs of nucleoside phosphonates (Inventor)
- Gak modulators as antivirals (Inventor)