Researcher
Steven De Jonghe
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 May 2017 → Today - Medicinal Chemistry (Rega Institute) (Division)
Member
From18 Feb 2002 → 30 Apr 2017
Projects
1 - 10 of 18
- Synthesis of agonists for the C-C chemokine receptor type 5 (CCR5), derived from a substituted 4-aminopiperidinyl lead structureFrom1 Jan 2023 → TodayFunding: BOF - doctoral mandates
- Optimisation of a triterpene lead compound for the development of pan-anticoronavirus drugs targeting nsp15From3 Jan 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Synthesis and structure-activity relationship studies of CCR8 agonists as a novel treatment option for autoimmune diseasesFrom27 Oct 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- The synthesis of novel CXCR4 antagonists for use in oncology and molecular imagingFrom1 Oct 2020 → 30 Sep 2021Funding: BOF - postdoctoral mandates
- An NMR facility tailored for biomedical researchFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Synthesis of nucleoside analogues as antiviral and antibacterial agentsFrom10 Feb 2020 → 10 Feb 2024Funding: Own budget, for example: patrimony, inscription fees, gifts
- Development and application of NanoBRET-based technology: Unravelling signalling bias at the human chemokine receptors CXCR1 and CXCR2From3 Sep 2019 → 3 Sep 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Synthesis of CXCR2 and CCR7 chemokine receptor antagonists targeting a conserved intracellular binding siteFrom3 Oct 2018 → 10 Jan 2023Funding: BOF - doctoral mandates
- Establishment of in vitro assays for the discovery of GPCR small molecule ligandsFrom30 May 2018 → 30 May 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- IN SEARCH FOR SUGAR, BASE OR PHOSPHATE MODIFIED NUCLEOSIDES ACTIVE AGAINST RNA VIRUSESFrom30 Nov 2017 → 7 Mar 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
31 - 40 of 129
- The discovery of Zika virus NS2B-NS3 inhibitors with antiviral activity via an integrated virtual screening approach(2022)
Authors: Steven De Jonghe, Dominique Schols, Mathy Froeyen
- Cytopathic SARS-CoV-2 screening on VERO-E6 cells in a large-scale repurposing effort(2022)
Authors: Dirk Jochmans, Steven De Jonghe, Kayvan Abbasi, Johan Neyts, Pieter Leyssen
- Development and optimization of a high-throughput screening assay for in vitro anti-SARS-CoV-2 activity: Evaluation of 5676 Phase 1 Passed Structures(2022)
Authors: Dirk Jochmans, Steven De Jonghe, Pieter Leyssen, Johan Neyts
Pages: 3101 - 3111 - Discovery of ( ±)-3-(1H-pyrazol-1-yl)-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4] thiadiazine derivatives with promising in vitro anticoronavirus and antitumoral activity(2022)
Authors: Dominique Schols, Steven De Jonghe, Dirk Daelemans
Pages: 1357 - 1371 - HIV protease inhibitors Nelfinavir and Lopinavir/Ritonavir markedly improve lung pathology in SARS-CoV-2-infected Syrian hamsters despite lack of an antiviral effect(2022)
Authors: Rana Abdelnabi, Suzanne Kaptein, Sebastiaan ter Horst, Leen Delang, Joana Duarte Da Rocha Pereira, Lotte Coelmont, Pieter Leyssen, Kai Dallmeier, Valentijn Vergote, Elisabeth Heylen, et al.
- Stimulation of the atypical chemokine receptor 3 (ACKR3) by a small-molecule agonist attenuates fibrosis in a preclinical liver but not lung injury model(2022)
Authors: Tom Van Loy, Steven De Jonghe, Wouter Dheedene, Patrick Chaltin, Aernout Luttun, Dominique Schols
- Discovery of 2-Phenylquinolines with Broad-Spectrum Anti- coronavirus Activity(2022)
Authors: Laura Vangeel, Dirk Jochmans, Dominique Schols, Johan Neyts, Steven De Jonghe
Pages: 855 - 864 - Identification of novel chemotypes as CXCR2 antagonists via a scaffold hopping approach from a thiazolo[5,4-d]pyrimidine(2022)
Authors: Max Van Hoof, Katrijn Boon, Tom Van Loy, Dominique Schols, Wim Dehaen, Steven De Jonghe
- A Set of Experimentally Validated Decoys for the Human CC Chemokine Receptor 7 (CCR7) Obtained by Virtual Screening(2022)
Authors: Steven De Jonghe, Tom Van Loy, Dominique Schols
- Ivermectin Does Not Protect against SARS-CoV-2 Infection in the Syrian Hamster Model(2022)
Authors: Rana Abdelnabi, Laura Vangeel, Steven De Jonghe, Dirk Jochmans, Birgit Weynand, Johan Neyts
Patents
1 - 10 of 10
- Isoquinoline and pyridine based cxcr4 antagonists (Inventor)
- Prodrugs of nucleoside phosphonates (Inventor)
- Novel prodrugs of nucleoside phosphonates (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Antiviral activity of bicyclic heterocycles (Inventor)
- Antiviral compounds, a process for their preparation, and their use for treating viral infections (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Purine analogues and their use as immunosuppressive agents (Inventor)
- Novel prodrugs of nucleoside phosphonates (Inventor)
- Gak modulators as antivirals (Inventor)