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Researcher
Steven De Jonghe
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 May 2017 → Today - Medicinal Chemistry (Rega Institute) (Division)
Member
From18 Feb 2002 → 30 Apr 2017
Projects
11 - 18 of 18
- Structure-based design and synthesis of nucleoside-triphosphate analogs as new classes of viral polymerase inhibitorsFrom25 Sep 2017 → 10 Sep 2021Funding: Own budget, for example: patrimony, inscription fees, gifts
- Synthesis and biological evaluation of MAS gene receptor X2 atagonistsFrom1 Jan 2016 → 1 Jan 2020Funding: FWO Strategic Basic Research Grant
- Synthesis and biological evaluation of C-nucleoside analoguesFrom25 Sep 2015 → 23 Sep 2019Funding: Own budget, for example: patrimony, inscription fees, gifts
- Synthesis and biological evaluation of Cyclin G-associated Kinase (GAK) inhibitors.From1 Jan 2015 → 31 Dec 2019Funding: IWT personal funding - strategic basic research grants
- Flavine dependent thymidylate synthase: a target for new antibiotics.From1 Jan 2012 → 31 Dec 2017Funding: FWO research project (including WEAVE projects)
- Synthesis of novel and drug-like compound libraries for screening across a broad range of therapeutic areas.From1 Oct 2010 → 30 Sep 2018Funding: IOF - Industrial Research Fund, IWT / VLAIO - excluding impulse programmes
- Design and synthesis of new compound libraries targeting kinasesFrom1 Sep 2009 → 14 Nov 2013Funding: Baekeland
- Synthesis and biological evaluation of inhibitors of the of UvrD helicaseMycobacterium tuberculosis.From1 Dec 2008 → 31 Jan 2013Funding: IWT personal funding - strategic basic research grants
Publications
1 - 10 of 129
- Identification of novel human CC chemokine receptor 8 (CCR8) antagonists via the synthesis of naphthalene amide and sulfonamide isosteres.(2024)
Authors: Dominique Schols, Steven De Jonghe
Pages: 107181 - Design, synthesis, and molecular modeling studies of novel 2-quinolone-1,2,3-triazole-α-aminophosphonates hybrids as dual antiviral and antibacterial agents.(2024)
Authors: Johan Neyts, Dirk Jochmans, Steven De Jonghe
Pages: 116235 - Synthesis of benzo[d]isothiazoles: an update(2024)
Authors: Yulia Ivanova, Steven De Jonghe, Wim Dehaen
- Development of a cellular model to study CCR8 signaling in tumor-infiltrating regulatory T cells(2024)
Authors: Libao Liu, Susan Schlenner, Steven De Jonghe, Dominique Schols, Tom Van Loy
- A new alkaloid from Pancratium maritimum - Structure elucidation using computer-assisted structure elucidation (CASE) and evaluation of cytotoxicity and anti-SARS-CoV-2 activity(2023)
Authors: Steven De Jonghe, Johan Neyts, Christophe Pannecouque
Pages: 1 - 7 - Synthesis and Biological Evaluation of 2-Substituted Quinazolin-4(3H)-Ones with Antiproliferative Activities(2023)
Authors: Dominique Schols, Steven De Jonghe
- Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.(2023)
Authors: Steven De Jonghe, Kim Donckers, Dirk Jochmans, Johan Neyts
Pages: eabo7201 - Synthesis of mizoribine prodrugs and their in vivo evaluation as immunosuppressive agents(2023)
Authors: Ling-Jie Gao, Steven De Jonghe, Mark Waer, Piet Herdewyn
- Photo-induced scandium-catalyzed biomimetic skeleton conversion of lathyrane to naturally rare eupholathone Euphorbia diterpenes(2023)
Authors: Steven De Jonghe
Pages: 12290 - 12293 - Photo-induced scandium-catalyzed biomimetic skeleton conversion of lathyrane to naturally rare eupholathone Euphorbia diterpenes(2023)
Authors: Steven De Jonghe, Dominique Schols
Pages: 12290 - 12293
Patents
1 - 10 of 10
- Isoquinoline and pyridine based cxcr4 antagonists (Inventor)
- Prodrugs of nucleoside phosphonates (Inventor)
- Novel prodrugs of nucleoside phosphonates (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Antiviral activity of bicyclic heterocycles (Inventor)
- Antiviral compounds, a process for their preparation, and their use for treating viral infections (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Purine analogues and their use as immunosuppressive agents (Inventor)
- Novel prodrugs of nucleoside phosphonates (Inventor)
- Gak modulators as antivirals (Inventor)