Synthesis of nucleoside analogues as antiviral and antibacterial agents

Resistance to current antibiotics is rapidly increasing in nowadays. One way to tackle this problem of antibiotic resistance, is the identification of structurally novel antibacterial agents, which are likely to have different modes of action is a priority. Within this project I propose to use the nucleoside scaffold as a core structure for the dicovery of novel antibacterials. It contains two series: 1) synthesis of 3'-modified ribo and 2'-deoxyribo nucleoside analogues. 2) synthesis of pseudouridymycin analogues.