Researcher
Sergei Strelkov
- Disciplines:Analytical chemistry, Medicinal and biomolecular chemistry, Biochemistry and metabolism, Molecular and cell biology, Plant biology, Systems biology, Biophysics, Medical biochemistry and metabolism, Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences
Affiliations
- Biocrystallography (Division)
Responsible
From1 Jan 2012 → Today - Biocrystallography (Division)
Member
From1 Dec 2005 → Today
Projects
1 - 10 of 38
- Design of targeted degraders of LEDGF/p75 with applications as anticancer agentsFrom25 Sep 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Molecular structure and pharmacological activation of LZTR1 towards novel anticancer therapiesFrom20 Aug 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Machine learning approaches to accelerate QM/MMFrom16 Aug 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Type III intermediate filaments: molecular structure to understand muscular diseaseFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- When size matters: a platform to study molecular interactions and multimerisationFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Structure-based design of inhibitors targeting the chromatin-reading function of LEDGF/p75 to treat acute mixed-lineage leukemiaFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- Rational discovery of drug compounds targeting the chromatin-reading function of LEDGF/p75 towards the treatment for acute MLL-rearranged leukemiaFrom10 Sep 2021 → TodayFunding: FWO Strategic Basic Research Grant
- A 200 kV transmission electron microscope for high-resolution determination of 3D-ultrastructure of native proteins, cells and tissueFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Crystallographic facility for target-based drug designFrom1 May 2020 → TodayFunding: FWO International research infrastructure (IRI)
- Development of new antimicrobials: Rational design of polyomavirus and mycobacterial inhibitorsFrom1 Oct 2019 → 23 Nov 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
81 - 90 of 103
- Stabilization of vimentin coil2 fragment via an engineered disulfide(2012)
Authors: Anastasia Chernyatina, Sergei Strelkov
Pages: 46 - 53 - Expression, purification and preliminary biochemical and structural characterization of the leucine rich repeat namesake domain of leucine rich repeat kinase 2(2012)
Authors: Renée Vancraenenbroeck, Evy Lobbestael, Stephen Weeks, Sergei Strelkov, Veerle Baekelandt, Jean-Marc Taymans, Marc De Maeyer
Pages: 450 - 460 - Three-Dimensional Structure of alpha-Crystallin Domain Dimers of Human Small Heat Shock Proteins HSPB1 and HSPB6(2011)
Authors: Ekaterina Baranova, Stephen Weeks, Sergei Strelkov
Pages: 110 - 122 - Structure based discovery and optimization of first-in-class inhibitors of the HIV-1 IN-LEDGF/p75 interaction(2011)
Authors: Arnout Voet, Frauke Christ, Arnaud Marchand, Patrick Chaltin, Stefan Nicolet, Sergei Strelkov, Zeger Debyser, Marc De Maeyer
Pages: 120 - 121 - Simultaneous Formation of Right- and Left-handed Anti-parallel Coiled-coil Interfaces by a Coil2 Fragment of Human Lamin A(2011)
Authors: Sergei Strelkov
Pages: 135 - 146 - Crystal Structures of a Cysteine-modified Mutant in Loop D of Acetylcholine-binding Protein(2011)
Authors: Steve Peigneur, Jan Tytgat, Sergei Strelkov, Chris Ulens
Pages: 4420 - 4428 - History and phylogeny of intermediate filaments: Now in insects(2011)
Authors: Harald Herrmann, Sergei Strelkov
Pages: 1 - 5 - History and phylogeny of intermediate filaments: Now in insects(2011)
Authors: Sergei Strelkov
Pages: 1 - 5 - Molecular Basis of Bacterial Defense against Host Lysozymes: X-ray Structures of Periplasmic Lysozyme Inhibitors PliI and PliC(2011)
Authors: Seppe Leysen, Joris Van Herreweghe, Lien Callewaert, Michelle Heirbaut, Chris Michiels, Sergei Strelkov
Pages: 1233 - 1245 - Crystallization and preliminary X-ray analysis of a cold-active endo-β-1,4-D-xylanase from glycoside hydrolase family 8(2011)
Authors: Annick Pollet, Jan Delcour, Sergei Strelkov, Christophe Courtin
Pages: 150 - 152