Researcher
Sergei Strelkov
- Disciplines:Analytical chemistry, Medicinal and biomolecular chemistry, Biochemistry and metabolism, Molecular and cell biology, Plant biology, Systems biology, Biophysics, Medical biochemistry and metabolism, Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences
Affiliations
- Biocrystallography (Division)
Responsible
From1 Jan 2012 → Today - Biocrystallography (Division)
Member
From1 Dec 2005 → Today
Projects
1 - 10 of 38
- Design of targeted degraders of LEDGF/p75 with applications as anticancer agentsFrom25 Sep 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Molecular structure and pharmacological activation of LZTR1 towards novel anticancer therapiesFrom20 Aug 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Machine learning approaches to accelerate QM/MMFrom16 Aug 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Type III intermediate filaments: molecular structure to understand muscular diseaseFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- When size matters: a platform to study molecular interactions and multimerisationFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Structure-based design of inhibitors targeting the chromatin-reading function of LEDGF/p75 to treat acute mixed-lineage leukemiaFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- Rational discovery of drug compounds targeting the chromatin-reading function of LEDGF/p75 towards the treatment for acute MLL-rearranged leukemiaFrom10 Sep 2021 → TodayFunding: FWO Strategic Basic Research Grant
- A 200 kV transmission electron microscope for high-resolution determination of 3D-ultrastructure of native proteins, cells and tissueFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Crystallographic facility for target-based drug designFrom1 May 2020 → TodayFunding: FWO International research infrastructure (IRI)
- Development of new antimicrobials: Rational design of polyomavirus and mycobacterial inhibitorsFrom1 Oct 2019 → 23 Nov 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
91 - 100 of 103
- Crystal structure of the noncompetitive xylanase inhibitor TLXI, member of the small thaumatin-like protein family(2010)
Authors: Elien Vandermarliere, Jan Schoepe, Ellen Fierens, Kurt Gebruers, Guido Volckaert, Anja Rabijns, Jan Delcour, Sergei Strelkov, Christophe Courtin
Pages: 2391 - 2394 - Subtle structural differences between human and mouse PAI-1 reveal the basis for biochemical differences(2010)
Authors: Maarten Dewilde, Sergei Strelkov, Ann Gils, Paul Declerck
Pages: 95 - 101 - Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication(2010)
Authors: Frauke Christ, Arnout Voet, Belete Ayele Desimmie, Sergei Strelkov, Marc De Maeyer, Patrick Chaltin, Zeger Debyser
Pages: 442 - 448 - Atomic structure of vimentin coil 2(2010)
Authors: Sergei Strelkov
Pages: 369 - 376 - Characterization of the Head-to-Tail Overlap Complexes Formed by Human Lamin A, B1 and B2 "Half-minilamin" Dimers(2010)
Authors: Sergei Strelkov
Pages: 719 - 731 - Functional analysis of glycoside hydrolase family 8 xylanases shows narrow but distinct substrate specificities and biotechnological potential(2010)
Authors: Annick Pollet, Jan Schoepe, Emmie Dornez, Sergei Strelkov, Jan Delcour, Christophe Courtin
Pages: 2125 - 2135 - The taming of small heat-shock proteins: crystallization of the alpha-crystallin domain from human Hsp27(2009)
Authors: Ekaterina Baranova, Sergei Strelkov
Pages: 1277 - 1281 - Intermediate filaments: primary determinants of cell architecture and plasticity(2009)
Authors: Sergei Strelkov
Pages: 1772 - 1783 - Crystallographic and activity-based evidence for thumb flexibility and its relevance in glycoside hydrolase family 11 xylanases(2009)
Authors: Annick Pollet, Elien Vandermarliere, Jeroen Lammertyn, Sergei Strelkov, Jan Delcour, Christophe Courtin
Pages: 395 - 403 - High quality structure of cleaved PAI-1-stab(2009)
Authors: Maarten Dewilde, Sergei Strelkov, Anja Rabijns, Paul Declerck
Pages: 126 - 132