Researcher
Serge Van Calenbergh
- Keywords:medicinal chemistry, nucleoside analogues, drug discovery, infectious diseases, glycosphingolipids
- Disciplines:Organic chemical synthesis, Bio-organic chemistry, Characterisation of biologically active (macro)molecules, Medicinal and biomolecular chemistry not elsewhere classified, Biomolecular modelling and design, Medicinal chemistry, Drug discovery and development not elsewhere classified
Affiliations
- Faculty Education Services Pharmaceutical Sciences (Administrative office)
Responsible
From1 Oct 2014 → 30 Sep 2022 - Faculty Education Services Pharmaceutical Sciences (Administrative office)
Member
From1 Oct 2014 → 30 Sep 2022 - Dean's Office of the Faculty of Pharmaceutical Sciences (Administrative office)
Member
From1 Sep 1997 → 31 Dec 1997 - Department of Pharmaceutics (Department)
Member
From1 Jan 1993 → Today
Projects
1 - 10 of 15
- Design and synthesis of inhibitors of the MEP pathwayFrom1 Jan 2024 → TodayFunding: BOF - doctoral mandates
- Uncaging the potential of photopharmacology for the treatment of epilepsyFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- Evaluation of a new treatment against "blackhead" disease in turkeys (POULTRY 2)From16 Oct 2023 → TodayFunding: IOF - technology validation in lab
- Cofunding core facility - NMR Expertise CentreFrom1 Oct 2023 → TodayFunding: BOF - research organisations
- Identification of optimized Aurora Kinase A PROTACs with suitable PK properties for in vivo proof-of-concept studies (OPTIMAPK).From15 Jul 2023 → TodayFunding: IOF - technology concept exploration
- Targeting transcription factor addiction in acute leukemia (TaTFAL)From1 Oct 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
- Targeting the degradation of proteins involved in neuroblastoma with bivalent ligands.From1 Nov 2020 → TodayFunding: FWO Strategic Basic Research Grant
- Novel treatment for blackhead disease in turkeysFrom3 Aug 2020 → 30 Jun 2022Funding: IOF - technology concept exploration
- Exploiting the methylerythritol phosphate pathway as a source of drug targets for novel anti-infectivesFrom1 Apr 2020 → TodayFunding: H2020-EU.1.3.- EXCELLEN SCIENCE - Marie Skłodowska-Curie actions
- Identification of adaptive mechanisms leading to reduced antibiotic susceptibility in bacterial biofilms using experimental evolution and machine learning approachesFrom1 Jan 2020 → TodayFunding: BOF - projects
Publications
11 - 20 of 38
- 6-O-alkylated 7-deazainosine nucleoside analogues : discovery of potent and selective anti-sleeping sickness agents(2020)
Authors: Fabian Hulpia, Jakob Bouton, Gustavo D. Campagnaro, Ibrahim A. Alfayez, Dorien Mabille, Louis Maes, Harry P. de Koning, Guy Caljon, Serge Van Calenbergh
- 1-(1-Arylethylpiperidin-4-yl)thymine analogs as antimycobacterial TMPK inhibitors(2020)
Authors: Yanlin Jian, Fabian Hulpia, Martijn Risseeuw, He Eun Forbes, Guy Caljon, Hélène Munier-Lehmann, Helena I. M. Boshoff, Serge Van Calenbergh
- Broadening the message : a nanovaccine co-loaded with messenger RNA and α-GalCer induces antitumor immunity through conventional and natural killer T cells(2019)
Authors: Rein Verbeke, Ine Lentacker, Karine Breckpot, Jonas Janssens, Serge Van Calenbergh, Stefaan De Smedt, Heleen Dewitte
Pages: 1655 - 1669 - Ceramide-templated macrolactams : total synthesis and biological evaluation of macrocyclic α-galactosylceramide analogues and their aglycons(2019)
Authors: Jonas Janssens, Johan Van der Eycken, Serge Van Calenbergh
Pages: 2253 - 2267 - Host metabolites stimulate the bacterial proton motive force to enhance the activity of aminoglycoside antibiotics(2019)
Authors: Aurélie Crabbé, Lisa Ostyn, Sorien Staelens, Charlotte Rigauts, Martijn Risseeuw, Maarten Dhaenens, Simon Daled, Heleen Van Acker, Dieter Deforce, Serge Van Calenbergh, et al.
- Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness(2019)
Authors: Fabian Hulpia, Dorien Mabille, Gustavo Daniel Campagnaro, Gabriela Schuman, Louis Maes, Isabel Roditi, Anders Hofer, Harry P de Koning, Guy Caljon, Serge Van Calenbergh
- 4''-O-Alkylated α-galactosylceramide analogues as iNKT-cell antigens : synthetic, biological, and structural studies(2019)
Authors: Jonas Janssens, Aruna Bitra, Jing Wang, Tine Decruy, Koen Venken, Johan Van der Eycken, Dirk Elewaut, Dirk Zajonc, Serge Van Calenbergh
Pages: 147 - 168 - New fluoroethyl phenylalanine analogues as potential LAT1-targeting PET tracers for glioblastoma(2019)
Authors: Jeroen Verhoeven, Fabian Hulpia, Ken Kersemans, Julie Bolcaen, Stef De Lombaerde, Jan Goeman, Benedicte Descamps, Giorgio Hallaert, Caroline Van den Broecke, Karel Deblaere, et al.
- Tailored design of sugar-modified a-GalCer analogues for Th1-polarized immune responses(2018)
Authors: Serge Van Calenbergh
Pages: 42 - 42 - Synthesis of a 3'-C-ethynyl-β-D-ribofuranose purine nucleoside library : discovery of C7-deazapurine analogs as potent antiproliferative nucleosides(2018)
Authors: Fabian Hulpia, Sam Noppen, Dominique Schols, Graciela Andrei, Robert Snoeck, Sandra Liekens, Peter Vervaeke, Serge Van Calenbergh
Pages: 248 - 267
Patents
1 - 10 of 10
- Nucleoside analogues for the treatment of parasitic infections (Inventor)
- Sphingamide Compounds and Methods for Binding iNKT Cells (Inventor)
- Nucleoside analogues for the treatment of parasitic infections (Inventor)
- Sphingamide Compounds and Methods for Binding iNKT Cells (Inventor)
- GALACTOPYRANOSYL DERIVATIVES USEFUL AS MEDICAMENTS (Inventor)
- Nucleoside analogues for the treatment of parasitic infections (Inventor)
- HAMAMELITANNIN ANALOGUES AND USES THEREOF (Inventor)
- HAMAMELITANNIN ANALOGUES AND USES THEREOF (Inventor)
- NOVEL HAMAMELITANNIN ANALOGUES AND USES THEREOF (Inventor)
- GALACTOPYRANOSYL DERIVATIVES USEFUL AS MEDICAMENTS (Inventor)