< Back to previous page
Researcher
Pieter Annaert
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences
Affiliations
- Department of Pharmaceutical and Pharmacological Sciences (Department)
Responsible
From1 Aug 2020 → Today - Drug Delivery and Disposition (Division)
Member
From1 Oct 2005 → Today
Projects
1 - 10 of 33
- Investigating current gaps in time-dependent inhibition (TDI) and induction drug-drug interactions (DDIs). A focus on CYP3A4 and non-CYPs drug metabolizing enzymes (DMEs).From24 May 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Improved clearance prediction using ex vivo and new in silico tools to bridge the in vitro to in vivo extrapolation (IVIVE) gapFrom1 Oct 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Investigation of bidirectional pharmacokinetic drug-drug interaction between vicagrel, a novel analogue for the antiplatelet drug clopidogrel, and atorvastatinFrom15 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Design and development of FabV inhibitors as a new class of antibacterials for pathogenic Gram-negative bacteriaFrom1 Oct 2021 → TodayFunding: Baekeland
- Predicting exposure of neonates to maternal medicines via breastfeedingFrom1 Oct 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Model-informed drug development: application to drug-induced cholestasisFrom1 Oct 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Drug exposure through lactation: providing neonatal physiology to improve pharmacokinetic predictionsFrom21 Sep 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Drug Design and Development: From Target to MarketFrom7 Jun 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Integrated PK/PM Model-based Medication Dosing Assist App(lication) in KlinischWerkStation (KWS). Validation Studies of Tacrolimus in (Solid) Organ TransplantationFrom1 Jan 2021 → 31 Dec 2023Funding: IOF - technology validation in lab
- In vitro and in silico investigation of pharmacokinetics in neonates undergoing therapeutic hypothermiaFrom26 Nov 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
11 - 20 of 253
- Physiologically based pharmacokinetic modelling to inform combination dosing regimens of ceftaroline and daptomycin in special populations(2023)
Authors: Pieter Annaert
- Pharmacokinetics during therapeutic hypothermia in neonates: from pathophysiology to translational knowledge and physiologically-based pharmacokinetic (PBPK) modeling(2023)
Authors: Karen Leys, Pieter Annaert, Sebastien Carpentier, Karel Allegaert, Anne Smits
Pages: 461 - 477 - Unravelling the Hepatic Elimination Mechanisms of Colistin(2023)
Authors: Matthias Gijsen, Tom De Vocht, Getahun Befirdu Abza, Nina Nauwelaerts, Joost Wauters, Pieter Annaert
Pages: 1723 - 1734 - Dose Adjustment in Patients with Liver Cirrhosis - Comparison of Two Different Modeling Approaches(2023)
Authors: Pieter Annaert
Pages: 1346 - 1358 - Generic Workflow to Predict Medicine Concentrations in Human Milk Using Physiologically-Based Pharmacokinetic (PBPK) Modelling—A Contribution from the ConcePTION Project(2023)
Authors: Nina Nauwelaerts, Miao-Chan Huang, Martje Van Neste, Anne Smits, Karel Allegaert, Pieter Annaert
- Safety of medicines during breastfeeding - from case report to modeling: a contribution from the ConcePTION project(2023)
Authors: Nina Nauwelaerts, Karel Allegaert, Anne Smits, Pieter Annaert
Pages: 269 - 283 - Development of a neonatal Gottingen Minipig model for dose precision in perinatal asphyxia: technical opportunities, challenges, and potential further steps(2023)
Authors: Karen Leys, Pieter Annaert, Sebastien Carpentier, Anne Smits, Karel Allegaert
- PBPK-based dose finding for sildenafil in pregnant women for antenatal treatment of congenital diaphragmatic hernia(2023)
Authors: Nina Nauwelaerts, Jan Deprest, Karel Allegaert, Pieter Annaert
- Sensitive and rapid method for the quantitation of amoxicillin in minipig plasma and milk by LC-MS/MS: A contribution from the IMI ConcePTION project.(2023)
Authors: Pieter Annaert
Pages: 107264 - Clinicopathological Features and Survival of Patients with Hepatocellular Carcinoma in Ethiopia: A Multicenter Study(2023)
Authors: Getahun Befirdu Abza, Pieter Annaert