Researcher
Pieter Annaert
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences
Affiliations
- Department of Pharmaceutical and Pharmacological Sciences (Department)
Responsible
From1 Aug 2020 → Today - Drug Delivery and Disposition (Division)
Member
From1 Oct 2005 → Today
Projects
11 - 20 of 33
- Development of a non-clinical platform for mechanistic studies of drug-induced cholestasisFrom8 Oct 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Development and streamlining a validation and implementation workflow for model-informed precision dosing for biologicals and antimicrobialsFrom1 Oct 2020 → 30 Sep 2022Funding: IOF - technology validation in lab
- I-PREDICT: Innovative Physiology-based pharmacokinetic model to pREdict Drug exposure In neonates undergoing Cooling TherapyFrom1 Jan 2020 → 31 Dec 2023Funding: FWO research project (including WEAVE projects)
- Development, characterization and validation of an in vitro/in silico platform to predict transfer of medicines to human breast milk along with neonatal systemic exposure to maternal medication.From3 Sep 2019 → TodayFunding: FWO Strategic Basic Research Grant
- Role of connexin and pannexin signaling in cholestasisFrom29 Mar 2019 → 11 Oct 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Pharmacokinetic boosting approach for tyrosine kinase inhibitors – Sorafenib and Lenvatinib – targeting hepatocellular carcinomaFrom1 Mar 2019 → 1 Mar 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Are connexin hemichannels and pannexin channels therapeutic drug targets and diagnostic biomarkers in cholestasis?From1 Jan 2018 → 31 Dec 2021Funding: FWO research project (including WEAVE projects)
- Use of fluorescent probes to study pharmacokinetics in zebrafish (Danio rerio) embryos and larvaeFrom12 Dec 2017 → 19 Nov 2021Funding: Own budget, for example: patrimony, inscription fees, gifts
- Computer-assisted dosing recommendation framework, feasibility study and proof of concept implementation for tacrolimusFrom1 Nov 2017 → 7 Sep 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- Drug-mediated modulation of hepatic bile salt transportersFrom1 Oct 2017 → 5 Oct 2021Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
1 - 10 of 252
- Determining the exposure of maternal medicines through breastfeeding: the UmbrelLACT study protocol - A contribution from the ConcePTION project(2024)
Authors: Martje Van Neste, Nina Nauwelaerts, Michael Ceulemans, Kristel Van Calsteren, An Eerdekens, Pieter Annaert, Karel Allegaert, Anne Smits
- Interdisciplinary Collaboration on Real World Data to Close the Knowledge Gap: A Reflection on "De Sutter et al. Predicting Volume of Distribution in Neonates: Performance of Physiologically Based Pharmacokinetic Modelling"(2024)
Authors: Karel Allegaert, Anne Smits, Pieter Annaert
- A Population Model of Time-Dependent Changes in Serum Creatinine in (Near)term Neonates with Hypoxic-Ischemic Encephalopathy During and After Therapeutic Hypothermia(2023)
Authors: Pieter Annaert, Djalila Mekahli, Anne Smits, Karel Allegaert
- Automated Generation of hiPSC-Derived Hepatic Progeny by Cost-Efficient Compounds(2023)
Authors: Kristof De Vos, Teresa Izuel Idoype, Pieter Annaert, Frederic Lluis Vinas, Catherine Verfaillie
Pages: 1076 - 1088 - Challenges Related to Acquisition of Physiological Data for Physiologically Based Pharmacokinetic (PBPK) Models in Postpartum, Lactating Women and Breastfed Infants—A Contribution from the ConcePTION Project(2023)
Authors: Martje Van Neste, Annick Bogaerts, Nina Nauwelaerts, Anne Smits, Pieter Annaert, Karel Allegaert
- PBPK Modelling for Drugs Cleared by Non-CYP Enzymes: State-of-the-Art and Future Perspectives.(2023)
Authors: Karen Leys, Pieter Annaert
Pages: DMD-AR-202 - Role of connexin and pannexin signaling in cholestasis(2023)
Authors: Axelle Cooreman, Pieter Annaert
- Assessment of in vitro antimicrobial activity of clindamycin metabolites against Staphylococcus species(2023)
Authors: Greet Van De Sijpe, Karel Allegaert, Jef Rozenski, Pieter Annaert, Stefanie Desmet
Pages: 1345 - 1347 - Assessment of in vitro antimicrobial activity of clindamycin metabolites against Staphylococcus species(2023)
Authors: Greet Van De Sijpe, Laura Armengol Álvarez, Agustos Cetin Ozbey, Karel Allegaert, Jef Rozenski, Pieter Annaert, Stefanie Desmet, Isabel Spriet
Pages: 1345 - 1347 - Physiologically based pharmacokinetic modelling to inform combination dosing regimens of ceftaroline and daptomycin in special populations(2023)
Authors: Pieter Annaert