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Project

Drug exposure through lactation: providing neonatal physiology to improve pharmacokinetic predictions

At present, there is little evidence-based advice on the intake of various drugs during pregnancy and lactation, with the result that a large percentage of medicines are not recommended during this period. Furthermore, there is a lack of scientific information on the effect of drugs in the neonate, more specifically on the pharmacokinetics of neonatal physiology. Because of the complex ethical dilemma, simulations are used to construct models based on neonatal physiology and mechanism. Through these simulations, within the approved IMI project ConcepTION, the predictability and clearance of drug exposure through breastfeeding in the neonate is investigated. From this, advice on harmless medication during breastfeeding can be based.

Date:21 Sep 2021 →  Today
Keywords:lactation, neonates
Disciplines:Pharmacokinetics
Project type:PhD project