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Researcher
Mathy Froeyen
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences, Bioinformatics and computational biology
Affiliations
- Department of Pharmaceutical and Pharmacological Sciences (Department)
Member
From1 Oct 2010 → 30 Sep 2011 - Medicinal Chemistry (Rega Institute) (Division)
Member
From1 Jul 2001 → Today - Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 1999 → 30 Jun 2001
Projects
1 - 10 of 11
- Molecular modelling tools to design artificial enzymesFrom18 Nov 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- An NMR facility tailored for biomedical researchFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Streamlining the route of phosphonate XNA from chemistry to applicationFrom1 Oct 2019 → 30 Sep 2023Funding: IOF - technology concept exploration, BOF - projects
- Exploring the Sequence and Functional Landscapes of Natural and Engineered PolymerasesFrom8 Oct 2018 → TodayFunding: FWO fellowships
- Drug design strategies against newly emerging viral diseasesFrom17 Oct 2016 → 30 Oct 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Investigations on base pairing between N8-glycosylated 8-aza-guanine bases and 8-substituted purine bases.From1 Jan 2016 → 31 Dec 2019Funding: FWO research project (including WEAVE projects)
- Development of XNA ligases as tools for synthetic biologyFrom22 Sep 2015 → 17 Oct 2019Funding: BOF - doctoral mandates, BOF - Doctoral projects
- Development of a xenozyme and an XNA ligase.From1 Oct 2014 → 30 Sep 2018Funding: BOF - Concerted Research Project from 1994
- Rational Design of XNA Processing EnzymesFrom22 Sep 2014 → 6 Oct 2020Funding: BOF - Doctoral projects
- Synthesis of modified nucleotides for application in medicine and biotechnology.From1 Jan 2012 → 31 Dec 2017Funding: FWO research project (including WEAVE projects)
Publications
11 - 20 of 113
- Effect of Berberis vulgaris L. root extract on ifosfamide-induced in vivo toxicity and in vitro cytotoxicity(2021)
Authors: Mathy Froeyen, Muhammad Usman Mirza
- Identification of novel human USP2 inhibitor and its putative role in treatment of COVID-19 by inhibiting SARS-CoV-2 papain-like (PLpro) protease(2020)
Authors: Muhammad Usman Mirza, Mathy Froeyen
- Discovery of HIV entry inhibitors via a hybrid CXCR4 and CCR5 receptor pharmacophore-based virtual screening approach(2020)
Authors: Muhammad Usman Mirza, Michiel Vanmeert, Steven De Jonghe, Dominique Schols, Mathy Froeyen
- New naphthalene derivative for cost-effective AChE inhibitors for Alzheimer's treatment: In silico identification, in vitro and in vivo validation(2020)
Authors: Mathy Froeyen, Muhammad Usman Mirza
- Discovery of human coronaviruses pan-papain-like protease inhibitors using computational approaches(2020)
Authors: Muhammad Usman Mirza, Mathy Froeyen
Pages: 546 - 559 - Drug design strategies against newly emerging viral diseases(2020)
Authors: Muhammad Usman Mirza, Mathy Froeyen, Jef Rozenski
- Rational Design of XNA Processing Enzymes(2020)
Authors: Michiel Vanmeert, Eveline Lescrinier, Mathy Froeyen, Vitor Bernardes Pinheiro
- Discovery of novel Hepatitis C virus inhibitor targeting multiple allosteric sites of NS5B polymerase(2020)
Authors: Mathy Froeyen, Muhammad Usman Mirza
- A Putative Prophylactic Solution for COVID-19: Development of Novel Multiepitope Vaccine Candidate against SARS-COV-2 by Comprehensive Immunoinformatic and Molecular Modelling Approach(2020)
Authors: Muhammad Usman Mirza, Mathy Froeyen
- Structural elucidation of SARS-CoV-2 vital proteins: Computational methods reveal potential drug candidates against main protease, Nsp12 polymerase and Nsp13 helicase(2020)
Authors: Muhammad Usman Mirza, Mathy Froeyen
Pages: 320 - 328