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Researcher
Mathy Froeyen
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences, Bioinformatics and computational biology
Affiliations
- Department of Pharmaceutical and Pharmacological Sciences (Department)
Member
From1 Oct 2010 → 30 Sep 2011 - Medicinal Chemistry (Rega Institute) (Division)
Member
From1 Jul 2001 → Today - Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 1999 → 30 Jun 2001
Projects
1 - 10 of 11
- Molecular modelling tools to design artificial enzymesFrom18 Nov 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- An NMR facility tailored for biomedical researchFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Streamlining the route of phosphonate XNA from chemistry to applicationFrom1 Oct 2019 → 30 Sep 2023Funding: IOF - technology concept exploration, BOF - projects
- Exploring the Sequence and Functional Landscapes of Natural and Engineered PolymerasesFrom8 Oct 2018 → TodayFunding: FWO fellowships
- Drug design strategies against newly emerging viral diseasesFrom17 Oct 2016 → 30 Oct 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Investigations on base pairing between N8-glycosylated 8-aza-guanine bases and 8-substituted purine bases.From1 Jan 2016 → 31 Dec 2019Funding: FWO research project (including WEAVE projects)
- Development of XNA ligases as tools for synthetic biologyFrom22 Sep 2015 → 17 Oct 2019Funding: BOF - doctoral mandates, BOF - Doctoral projects
- Development of a xenozyme and an XNA ligase.From1 Oct 2014 → 30 Sep 2018Funding: BOF - Concerted Research Project from 1994
- Rational Design of XNA Processing EnzymesFrom22 Sep 2014 → 6 Oct 2020Funding: BOF - Doctoral projects
- Synthesis of modified nucleotides for application in medicine and biotechnology.From1 Jan 2012 → 31 Dec 2017Funding: FWO research project (including WEAVE projects)
Publications
31 - 40 of 112
- Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3-b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity(2019)
Authors: Sven Verdonck, Mathy Froeyen, Ling-Jie Gao, Piet Herdewyn, Steven De Jonghe
Pages: 5810 - 5831 - Quantification of Berberine in Berberis vulgaris L. Root Extract and Its Curative and Prophylactic Role in Cisplatin-Induced In Vivo Toxicity and In Vitro Cytotoxicity(2019)
Authors: Mathy Froeyen, Muhammad Usman Mirza
- In silico structural elucidation of RNA-dependent RNA polymerase towards the identification of potential Crimean-Congo Hemorrhagic Fever Virus inhibitors(2019)
Authors: Muhammad Usman Mirza, Michiel Vanmeert, Mathy Froeyen
- In vitro evaluation of arylsubstituted imidazoles derivatives as antiprotozoal agents and docking studies on sterol 14-demethylase (CYP51) from Trypanosoma cruzi, Leishmania infantum, and Trypanosoma brucei(2019)
Authors: Mathy Froeyen
Pages: 1533 - 1548 - Inhibition of Oncogenic Kinases: An In Vitro Validated Computational Approach Identified Potential Multi-Target Anticancer Compounds(2019)
Authors: Muhammad Usman Mirza, Michiel Vanmeert, Mathy Froeyen
- Mutagenesis of DsbAss is Crucial for the Signal Recognition Particle Mechanism in Escherichia coli: Insights from Molecular Dynamics Simulations(2019)
Authors: Muhammad Usman Mirza, Mathy Froeyen
- Cyclin G-associated kinase (GAK) affinity and antiviral activity studies of a series of 3-C-substituted isothiazolo[4,3-b]pyridines.(2019)
Authors: Mathy Froeyen, Eveline Lescrinier, Piet Herdewyn, Steven De Jonghe
Pages: 256 - 265 - 1-(Piperidin-3-yl)thymine amides as inhibitors of M. tuberculosis thymidylate kinase(2019)
Authors: Mathy Froeyen
Pages: 1730 - 1739 - Chimeric XNA: An Unconventional Design for Orthogonal Informational Systems(2018)
Authors: Mathy Froeyen, Piet Herdewyn
Pages: 12811 - 12819 - Methylated Nucleobases: Synthesis and Evaluation for Base Pairing In Vitro and In Vivo(2018)
Authors: Amit Jabgunde, Mathy Froeyen, Mikhail Abramov, Eveline Lescrinier, Vitor Bernardes Pinheiro, Piet Herdewyn
Pages: 12695 - 12707