Researcher
Jan Parys
- Disciplines:Laboratory medicine, Palliative care and end-of-life care, Regenerative medicine, Other basic sciences, Other health sciences, Nursing, Other paramedical sciences, Other translational sciences, Other medical and health sciences
Affiliations
- Laboratory of Molecular and Cellular Signaling (Division)
Member
From1 Oct 2007 → Today
Projects
1 - 10 of 17
- A kinetic, high-throughput cellular screening system (Plate Imaging Reader) for the "real time" monitoring of dynamic intracellular Ca2+ signals in living cellsFrom1 May 2020 → TodayFunding: BOF - scientific equipment program
- Bcl-2/Bcl-XL proteins as modulators of calcium signaling through IP3 receptors: from novel molecular mechanisms to implications for therapeuticsFrom1 Oct 2019 → 30 Sep 2023Funding: IOF - technology concept exploration, BOF - projects
- Physiological significance of pyruvate kinase M2 interaction with the IP3 receptor and its application as a new way to induce apoptosis.From1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- A star is born: TBMIM5 as a novel Ca2+ channel at the inner mitochondrial membraneFrom1 Oct 2016 → 21 Jan 2021Funding: BOF - doctoral mandates
- Novel insights in the interplay between ryanodine receptors and Bcl-2 proteins.From1 Oct 2015 → 30 Sep 2016Funding: BOF - Other initiatives
- Crosstalk in the Ca2+ microdomain between lysosomes and endoplasmic reticulum controls the autophagic process.From1 Jan 2015 → 31 Dec 2018Funding: FWO research project (including WEAVE projects)
- Insights into the pathways implicated in the addiction of cancer B-cells to Bcl-2 at the endoplasmic reticulumFrom1 Oct 2014 → 30 Sep 2018Funding: FWO fellowships
- The role of lysosomal Ca2+ in the regulation of autophagyFrom1 Sep 2014 → 10 Dec 2019Funding: FWO fellowships, BOF - Doctoral projects
- A novel concept in the biology of Bcl-2 proteins: primed to death at the endoplasmic reticulum.From1 Jan 2014 → 31 Dec 2017Funding: FWO research project (including WEAVE projects)
- Interplay between the endoplasmic reticulum, Ca2+ and autophagy induced by various stressorsFrom1 Jan 2013 → 31 Dec 2016Funding: FWO research project (including WEAVE projects)
Publications
121 - 130 of 160
- Profiling of the Bcl-2/Bcl-X(L)-binding sites on type 1 IP(3) receptor(2012)
Authors: Giovanni Monaco, Hristina Ivanova, Ludwig Missiaen, Jan Parys, Humbert De Smedt, Geert Bultynck
Pages: 31 - 35 - Bax Inhibitor-1 is a novel IP(3) receptor-interacting and -sensitizing protein(2012)
Authors: Santeri Kiviluoto, Tim Vervliet, Ludwig Missiaen, Humbert De Smedt, Jan Parys, Geert Bultynck
- RhoA GTPase Switch Controls Cx43-Hemichannel Activity through the Contractile System(2012)
Authors: Raf Ponsaerts, Catheleyne D'hondt, Jan Parys, Johan Vereecke, Bernard Himpens, Geert Bultynck
- Role of the inositol 1,4,5-trisphosphate receptor/Ca2+-release channel in autophagy(2012)
Authors: Jan Parys, Jean-Paul Decuypere, Geert Bultynck
Pages: 17 - Polycystin-1 and polycystin-2 are both required to amplify inositol-trisphosphate-induced Ca2+ release(2012)
Authors: Djalila Mekahli, Eva Sammels, Bert van den Heuvel, Elena Levtchenko, Rik Gijsbers, Geert Bultynck, Jan Parys, Humbert De Smedt, Ludwig Missiaen
Pages: 452 - 458 - Guidelines for the use and interpretation of assays for monitoring autophagy(2012)
Authors: Patrizia Agostinis, Jan Parys, Wim Vandenberghe, Ilse Vanhorebeek, Geert Bultynck, Marc Fransen, Maria Garmyn, Jan Gunst, Karin Thevissen, Bo Liu, et al.
Pages: 445 - 544 - IP3 receptor-binding partners in cell-death mechanisms(2012)
Authors: Santeri Kiviluoto, Haidar Akl, Tim Vervliet, Geert Bultynck, Jan Parys, Ludwig Missiaen, Humbert De Smedt
Pages: 201 - 210 - Selective regulation of IP(3)-receptor-mediated Ca(2+) signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl(2012)
Authors: Giovanni Monaco, Haidar Akl, Raf Ponsaerts, Tim Vervliet, Marc De Maeyer, Ludwig Missiaen, Humbert De Smedt, Jan Parys, Geert Bultynck
Pages: 295 - 309 - Regulation of inositol 1,4,5-trisphosphate receptor function during mouse oocyte maturation(2012)
Authors: Veerle Vanderheyden, Jan Parys
Pages: 705 - 17 - The C Terminus of Bax Inhibitor-1 Forms a Ca2+-permeable Channel Pore(2012)
Authors: Geert Bultynck, Santeri Kiviluoto, Hristina Ivanova, Koen Nuyts, Wim De Borggraeve, Jan Parys, Humbert De Smedt, Ludwig Missiaen
Pages: 2544 - 2557