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Researcher
Jan Parys
- Disciplines:Laboratory medicine, Palliative care and end-of-life care, Regenerative medicine, Other basic sciences, Other health sciences, Nursing, Other paramedical sciences, Other translational sciences, Other medical and health sciences
Affiliations
- Laboratory of Molecular and Cellular Signaling (Division)
Member
From1 Oct 2007 → Today
Projects
11 - 17 of 17
- Nieuwe functies voor het BH4 domein van Bcl-2: een kritische regulator van Ca2+-permeable kanalen.From1 Jan 2012 → 31 Dec 2015Funding: FWO research project (including WEAVE projects)
- Molecular determinants of Bcl–2 and Bcl–Xl binding to the IP3R channel and regulation of its activity at the molecular and functional level in normal and apoptotic cellsFrom1 Oct 2011 → 30 Sep 2017Funding: FWO fellowships
- Identification of the MPM-2 sites on the inositol 1,4,5-trisphosphate receptor type 1 (IP3R1) and regulation of IP3R1 function by MPM-2 phosphorylation furing oocyte maturation.From1 Oct 2009 → 30 Sep 2010Funding: FWO fellowships
- Role of inositol 1,4,5-trisphosphate receptors and inositol 1,4,5-induced Ca2+ release in autophagy.From1 Jan 2009 → 31 Dec 2012Funding: FWO research project (including WEAVE projects)
- Calcium-transport proteins: mechanisms of function and their role in disease.From1 Oct 2008 → 30 Sep 2013Funding: BOF - Concerted Research Project from 1994
- Regulation of intracellular Ca2+ signalling by the anti-apoptotic Bcl-2-family members.From1 Sep 2008 → 30 Sep 2013Funding: FWO fellowships
- Molecular and functional characterization of the IP3R protein complexes with Beclin-1 and Bcl2/BclXl during autophagy.From1 Jan 2008 → 31 Dec 2011Funding: IWT personal funding - strategic basic research grants
Publications
1 - 10 of 160
- The interplay between associated proteins, redox state and Ca2+in the intraluminal ER compartment regulates the IP3 receptor(2024)
Authors: Jan Parys
- The Complex Effects of PKM2 and PKM2:IP3R Disruption on Intracellular Ca2+ Handling and Cellular Functions(2023)
Authors: Geert Bultynck, Jan Parys
- Modalities of cell death, survival and adaptation: The role of the Ca2+-signaling toolkit(2023)
Authors: Jan Parys, Geert Bultynck
- LRRK2 phosphorylation status and kinase activity regulate (macro)autophagy in a Rab8a/Rab10-dependent manner(2023)
Authors: Rita La Rovere, Evy Lobbestael, Veerle Baekelandt, Geert Bultynck, Jan Parys
- The ER-mitochondria interface, where Ca2+and cell death meet(2023)
Authors: Martijn Kerkhofs, Jens Loncke, Geert Bultynck, Jan Parys
- Modulation of Ca2+signaling by antiapoptotic Bcl-2 versus Bcl-xL: From molecular mechanisms to relevance for cancer cell survival(2022)
Authors: Nicolas Rosa, Jan Parys, Geert Bultynck
- Sec61 complex/translocon: The role of an atypical ER Ca2+-leak channel in health and disease(2022)
Authors: Jan Parys
- TMBIM5 loss of function alters mitochondrial matrix ion homeostasis and causes a skeletal myopathy(2022)
Authors: Jan Parys, Geert Bultynck
- Rhomboid pseudoproteases: An Achilles heel's for BCL-2/IP3R-dependent resistance to ER stress-induced cell death(2022)
Authors: Geert Bultynck, Jan Parys
- Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis(2022)
Authors: Nicolas Rosa, Rita La Rovere, Nikolaos Louros, Lily Karamanou, Frederic Rousseau, Joost Schymkowitz, Tassos Economou, Jan Parys, Geert Bultynck
Pages: 788 - 805