Researcher
Georges Leclercq
- Keywords:human, function, NK cells, differentiation, transcription factors
- Disciplines:Adaptive immunology, Applied immunology, Autoimmunity, Immunogenetics, Innate immunity, Hematology
Affiliations
- Department of Diagnostic Sciences (Department)
Member
From1 Oct 2018 → 28 Feb 2023 - Department of Clinical chemistry, microbiology and immunology (Department)
Member
From1 Jan 1993 → 30 Sep 2018
Projects
1 - 7 of 7
- Strengthening the UGent patent position on an improved cultivation method for adoptive cell therapies (immuno-oncology).From1 Apr 2019 → 31 Mar 2020Funding: IOF - technology concept exploration
- Innate lymphoid cells in multiple sclerosis: implications of genetic risk variantsFrom1 Jan 2018 → 31 Dec 2019Funding: Foundations, funds and other with scientific goal
- Transcriptional regulation of differentiation of human natural killer and innate lymphoid cells.From1 Jan 2017 → 31 Dec 2020Funding: FWO research project (including WEAVE projects)
- A new mechanism of tumor escape from innate-like T lymphocytesFrom1 Jan 2015 → 31 Dec 2018Funding: Foundations, funds and other with scientific goal
- The role of the transcription factors Ets-1, E4BP4 and GATA-3 in the development of human natural killer cells.From1 Oct 2012 → 1 Oct 2014Funding: BOF - Other initiatives
- Yellow/Green laser upgrade for LSRII analyser and FACSARIAII sorter flow cytometersFrom15 Jun 2012 → 30 Jun 2016Funding: BOF - Other initiatives
- A flow cytometer to perform multiparameter sorting, including single-cell deposition under biohazard conditions L2From1 Jan 2009 → 31 Dec 2010Funding: BOF - Other initiatives
Publications
41 - 50 of 79
- In vitro generation of mature, naive antigen-specific CD8⁺ T cells with a single T-cell receptor by agonist selection(2014)
Authors: Sylvia Snauwaert, Greet Verstichel, Glenn Goetgeluk, Yasmine Van Caeneghem, Katrien De Mulder, Carlo Heirman, Hans Stauss, Miriam HM Heemskerk, Tom Taghon, Georges Leclercq, et al.
Pages: 830 - 841 - Notch3 activation is sufficient but not required for inducing human T-lineage specification(2014)
Authors: Els Waegemans, Inge Van de Walle, Jelle De Medts, Magda De Smedt, Georges Leclercq, Tao Wang, Jean Plum, Tom Taghon
Pages: 5997 - 6004 - In vitro human embryonic stem cell hematopoiesis mimics MYB independent yolk sac hematopoiesis(2014)Volume: 42
Authors: Stijn Vanhee, Katrien De Mulder, Yasmine Van Caeneghem, Nadine Van Roy, Björn Menten, Imke Velghe, Jan Philippé, Tom Taghon, Georges Leclercq, Tessa Kerre, et al.
Pages: S63 - S63 - Ly49E Expression on CD8αα-expressing intestinal intraepithelial lymphocytes plays no detectable role in the development and progression of experimentally induced inflammatory bowel diseases(2014)
Authors: Aline Van Acker, Jessica Filtjens, Sophie Van Welden, Sylvie Taveirne, Els Van Ammel, Mandy Vanhees, Tom Taghon, Jean Plum, Georges Leclercq
- Abundant stage-dependent Ly49E expression by liver NK cells is not essential for their differentiation and function(2013)
Authors: Jessica Filtjens, Sylvie Taveirne, Aline Van Acker, Els Van Ammel, Mandy Vanhees, Tom Taghon, Jean Plum, Georges Leclercq
Pages: 699 - 711 - Mitochondrial ROS is involved during TNF-A-INDUCED oxidative stress in intestinal epthelial cells(2013)Volume: 76
Authors: Dinesh Nithyananda Babu, Georges Leclercq, Quinten Remijsen, Roberto Motterlini
Number of pages: 1 - CMYB expression during human in vitro hematopoiesis(2013)Volume: 41
Authors: Stijn Vanhee, Yasmine Van Caeneghem, Katrien De Mulder, Imke Velghe, Sylvie Taveirne, Nadine Van Roy, Björn Menten, Sylvia Snauwaert, Greet Verstichel, Melissa Dullaers, et al.
Pages: S33 - S33 - Education of murine NK cells requires both cis and trans recognition of MHC class I molecules(2013)
Authors: Stéphanie Bessoles, Georgi S Angelov, Jonathan Back, Georges Leclercq, Eric Vivier, Werner Held
Pages: 5044 - 5051 - Differential Ly49e expression pathways in resting versus TCR-activated intraepithelial γδ T cells(2013)
Authors: Tina Van Den Broeck, Els Van Ammel, Maarten Delforche, Sylvie Taveirne, Tom Taghon, Jean Plum, Georges Leclercq
Pages: 1982 - 1990 - β-Glucan microparticles are good candidates for mucosal antigen delivery in oral vaccination(2013)
Authors: Rebecca De Smet, Tine Demoor, Stephanie Verschuere, Melissa Dullaers, Gary R Ostroff, Georges Leclercq, Liesbeth Allais, Charles Pilette, Marijke Dierendonck, Bruno De Geest, et al.
Pages: 671 - 678
Patents
1 - 2 of 2
- Accelerated human hematopoietic stem cell differentiation towards mature Natural Killer cells with enhanced antibody-dependent cytotoxic activity (Inventor)
- Accelerated human hematopoietic stem cell differentiation towards mature Natural Killer cells with enhanced antibody-dependent cytotoxic activity (Inventor)