Researcher
Georges Leclercq
- Keywords:human, function, NK cells, differentiation, transcription factors
- Disciplines:Adaptive immunology, Applied immunology, Autoimmunity, Immunogenetics, Innate immunity, Hematology
Affiliations
- Department of Diagnostic Sciences (Department)
Member
From1 Oct 2018 → 28 Feb 2023 - Department of Clinical chemistry, microbiology and immunology (Department)
Member
From1 Jan 1993 → 30 Sep 2018
Projects
1 - 7 of 7
- Strengthening the UGent patent position on an improved cultivation method for adoptive cell therapies (immuno-oncology).From1 Apr 2019 → 31 Mar 2020Funding: IOF - technology concept exploration
- Innate lymphoid cells in multiple sclerosis: implications of genetic risk variantsFrom1 Jan 2018 → 31 Dec 2019Funding: Foundations, funds and other with scientific goal
- Transcriptional regulation of differentiation of human natural killer and innate lymphoid cells.From1 Jan 2017 → 31 Dec 2020Funding: FWO research project (including WEAVE projects)
- A new mechanism of tumor escape from innate-like T lymphocytesFrom1 Jan 2015 → 31 Dec 2018Funding: Foundations, funds and other with scientific goal
- The role of the transcription factors Ets-1, E4BP4 and GATA-3 in the development of human natural killer cells.From1 Oct 2012 → 1 Oct 2014Funding: BOF - Other initiatives
- Yellow/Green laser upgrade for LSRII analyser and FACSARIAII sorter flow cytometersFrom15 Jun 2012 → 30 Jun 2016Funding: BOF - Other initiatives
- A flow cytometer to perform multiparameter sorting, including single-cell deposition under biohazard conditions L2From1 Jan 2009 → 31 Dec 2010Funding: BOF - Other initiatives
Publications
1 - 10 of 79
- Type 1 immunity enables neonatal thymic ILC1 production(2024)
Authors: Peter Tougaard, Mario Ruiz Pérez, Wolf Steels, Jelle Huysentruyt, Bruno Verstraeten, Jessica Vetters, Tatyana Divert, Amanda Gonçalves, Ria Roelandt, Nozomi Takahashi, et al.
- Single-cell profiling identifies a novel human polyclonal unconventional T cell lineage(2023)
Authors: Lore Billiet, Laurenz De Cock, Guillem Sanchez Sanchez, Rupert Mayer, Glenn Goetgeluk, Stijn De Munter, Melissa Pille, Joline Ingels, Hanne Jansen, Karin Weening, et al.
- The Wiskott–Aldrich syndrome protein is required for positive selection during T-cell lineage differentiation(2023)
Authors: John Avila, Guillem Sanchez Sanchez, Glenn Goetgeluk, Stijn De Munter, Hanne Jansen, Lore Billiet, Karin Weening, Haipeng Xue, Eva Pascal, Lucas Deseins, et al.
- Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF(2023)
Authors: Kai Ling Liang, Juliette Roels, Marieke Lavaert, Tom Putteman, Lena Böhme, Laurentijn Tilleman, Imke Velghe, Valentina Pegoretti, Inge Van de Walle, Stephanie Sontag, et al.
Pages: 474 - 486 - Transcriptional dynamics and epigenetic regulation of E and ID protein encoding genes during human T cell development(2022)
Authors: Juliette Roels, Jolien Van Hulle, Marieke Lavaert, Anna Kuchmiy, Steven Strubbe, Tom Putteman, Bart Vandekerckhove, Georges Leclercq, Filip Van Nieuwerburgh, Lena Böhme, et al.
- TXNIP promotes human NK cell development but is dispensable for NK cell functionality(2022)
Authors: Sigrid Wahlen, Sylvie Taveirne, Wouter Van Loocke, Els Van Ammel, Filip Van Nieuwerburgh, Tom Taghon, Pieter Van Vlierberghe, Georges Leclercq
- Severe COVID-19 patients display hyper-activated NK cells and NK cell-platelet aggregates(2022)
Authors: Bert Malengier-Devlies, Jessica Filtjens, Kourosh Ahmadzadeh, Bram Boeckx, Jessica Vandenhaute, Amber De Visscher, Eline Bernaerts, Tania Mitera, Cato Jacobs, Lore Vanderbeke, et al.
- Small-scale manufacturing of neoantigen-encoding messenger RNA for early-phase clinical trials(2022)
Authors: Rupert Mayer, Pam Devreker, Karin Weening, Nele Lootens, Saskia De Smet, Marieke Brusseel, Stijn De Munter, Lore Billiet, Glenn Goetgeluk, Hanne Jansen, et al.
Pages: 213 - 222 - Treatment of a patient with severe cytomegalovirus (CMV) infection after haploidentical stem cell transplantation with donor-derived CMV-specific T cells(2021)
Authors: Saskia De Smet, Kelly Heyns, Nele Lootens, Jonas Segaert, Tom Taghon, Georges Leclercq, Karim Vermaelen, Evelyne Willems, Etienne Baudoux, Frédéric Baron
Pages: 482 - 486 - HES1 and HES4 have non-redundant roles downstream of Notch during early human T-cell development(2021)
Authors: Matthias De Decker, Marieke Lavaert, Laurentijn Tilleman, Georges Leclercq, Filip Van Nieuwerburgh, Pieter Van Vlierberghe, Tom Taghon
Pages: 130 - 141
Patents
1 - 2 of 2
- Accelerated human hematopoietic stem cell differentiation towards mature Natural Killer cells with enhanced antibody-dependent cytotoxic activity (Inventor)
- Accelerated human hematopoietic stem cell differentiation towards mature Natural Killer cells with enhanced antibody-dependent cytotoxic activity (Inventor)