Researcher
Georges Leclercq
- Keywords:human, function, NK cells, differentiation, transcription factors
- Disciplines:Adaptive immunology, Applied immunology, Autoimmunity, Immunogenetics, Innate immunity, Hematology
Affiliations
- Department of Diagnostic Sciences (Department)
Member
From1 Oct 2018 → 28 Feb 2023 - Department of Clinical chemistry, microbiology and immunology (Department)
Member
From1 Jan 1993 → 30 Sep 2018
Projects
1 - 7 of 7
- Strengthening the UGent patent position on an improved cultivation method for adoptive cell therapies (immuno-oncology).From1 Apr 2019 → 31 Mar 2020Funding: IOF - technology concept exploration
- Innate lymphoid cells in multiple sclerosis: implications of genetic risk variantsFrom1 Jan 2018 → 31 Dec 2019Funding: Foundations, funds and other with scientific goal
- Transcriptional regulation of differentiation of human natural killer and innate lymphoid cells.From1 Jan 2017 → 31 Dec 2020Funding: FWO research project (including WEAVE projects)
- A new mechanism of tumor escape from innate-like T lymphocytesFrom1 Jan 2015 → 31 Dec 2018Funding: Foundations, funds and other with scientific goal
- The role of the transcription factors Ets-1, E4BP4 and GATA-3 in the development of human natural killer cells.From1 Oct 2012 → 1 Oct 2014Funding: BOF - Other initiatives
- Yellow/Green laser upgrade for LSRII analyser and FACSARIAII sorter flow cytometersFrom15 Jun 2012 → 30 Jun 2016Funding: BOF - Other initiatives
- A flow cytometer to perform multiparameter sorting, including single-cell deposition under biohazard conditions L2From1 Jan 2009 → 31 Dec 2010Funding: BOF - Other initiatives
Publications
21 - 30 of 79
- Innate lymphoid cells in the upper airways : importance of CD117 and IL-1RI expression(2018)
Authors: Koen Van Crombruggen, Sylvie Taveirne, Gabriële Holtappels, Georges Leclercq, Claus Bachert
- Comparative analysis of the immune responses induced by native versus recombinant versions of the ASP-based vaccine against the bovine intestinal parasite Cooperia oncophora(2018)
Authors: Ana González Hernández, Jimmy Borloo, Iris Peelaers, Stijn Casaert, Georges Leclercq, Edwin Claerebout, Peter Geldhof
Pages: 41 - 49 - Differential effects of CORM-2 and CORM-401 in murine intestinal epithelial MODE-K cells under oxidative stress(2017)
Authors: Dinesh Nithyananda Babu, Georges Leclercq, Roberto Motterlini
- A murine intestinal intraepithelial NKp46-negative innate lymphoid cell population characterized by group 1 properties(2017)
Authors: Aline Van Acker, Konrad Gronke, Aindrila Biswas, Liesbet Martens, Yvan Saeys, Jessica Filtjens, Sylvie Taveirne, Els Van Ammel, Patrick Matthys, Tom Taghon, et al.
Pages: 1431 - 1443 - Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities(2017)
Authors: Yasmine Van Caeneghem, Stijn De Munter, Paola Tieppo, Glenn Goetgeluk, Karin Weening, Greet Verstichel, Tom Taghon, Georges Leclercq, Reno Debets, David Vermijlen, et al.
- Inflammatory gene expression profile and defective interferon-γ and granzyme K in natural killer cells from systemic juvenile idiopathic arthritis patients(2017)
Authors: Karen Put, Jessica Vandenhaute, Anneleen Avau, Annemarie van Nieuwenhuijze, Ellen Brisse, Tim Dierckx, Omer Rutgeerts, Josselyn E Garcia-Perez, Jaan Toelen, Mark Waer, et al.
Pages: 213 - 224 - Porcine NK cells display features associated with antigen-presenting cells(2017)
Authors: Steffi De Pelsmaeker, Bert Devriendt, Georges Leclercq, Herman Favoreel
Pages: 129 - 140 - The checkpoint for agonist selection precedes conventional selection in human thymus(2017)
Authors: Greet Verstichel, David Vermijlen, Liesbet Martens, Glenn Goetgeluk, Margreet Brouwer, Nicolas Thiault, Yasmine Van Caeneghem, Stijn De Munter, Karin Weening, Sarah Bonte, et al.
- Expression of the inhibitory Ly49E receptor is not critically involved in the immune response against cutaneous, pulmonary or liver tumours(2016)
Authors: Jessica Filtjens, Jiri Keirsse, Els Van Ammel, Sylvie Taveirne, Aline Van Acker, Tom Taghon, Jean Plum, Jo A Van Ginderachter, Georges Leclercq
- GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate(2016)
Authors: Inge Van de Walle, Anne-Catherine Dolens, Katrien De Mulder, Wouter Van Loocke, Sagar Damle, Els Waegemans, Jelle De Medts, Imke Velghe, Magda De Smedt, Jean Plum, et al.
Patents
1 - 2 of 2
- Accelerated human hematopoietic stem cell differentiation towards mature Natural Killer cells with enhanced antibody-dependent cytotoxic activity (Inventor)
- Accelerated human hematopoietic stem cell differentiation towards mature Natural Killer cells with enhanced antibody-dependent cytotoxic activity (Inventor)