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Researcher
Erik De Clercq
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 1999 → 30 Sep 2013
Publications
11 - 20 of 564
- The magic of a methyl group: Biochemistry at the service of medicine(2023)
Authors: Erik De Clercq
- Approved HIV reverse transcriptase inhibitors in the past decade(vol 12, pg 1567, 2022)(2023)
Authors: Erik De Clercq
Pages: 3581 - 3581 - Design, synthesis, and mechanistic study of 2-piperazineone-bearing peptidomimetics as novel HIV capsid modulators(2023)
Authors: Erik De Clercq, Christophe Pannecouque
Pages: 1272 - 1295 - Picomolar inhibitor of reverse transcriptase featuring significantly improved metabolic stability(2023)
Authors: Christophe Pannecouque, Erik De Clercq
Pages: 3054 - 3066 - Discovery of novel sulfonamide substituted indolylarylsulfones as potent HIV-1 inhibitors with better safety profiles(2023)
Authors: Erik De Clercq, Christophe Pannecouque
Pages: 2747 - 2764 - Therapeutic strategies for COVID-19: progress and lessons learned(2023)
Authors: Erik De Clercq
Pages: 449 - 475 - Escaping from Flatland: Multiparameter Optimization Leads to the Discovery of Novel Tetrahydropyrido[4,3-d]pyrimidine Derivatives as Human Immunodeficiency Virus-1 Non-nucleoside Reverse Transcriptase Inhibitors with Superior Antiviral Activities against Non-nucleoside Reverse Transcriptase Inhibitor-Resistant Variants and Favorable Drug-like Profiles(2023)
Authors: Erik De Clercq, Christophe Pannecouque
Pages: 8643 - 8665 - Hydrogen Bonding (Base Pairing) in Antiviral Activity(2023)
Authors: Erik De Clercq
- Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors(2023)
Authors: Erik De Clercq, Christophe Pannecouque
- Fragment Hopping-Based Design of Novel Biphenyl-DAPY Derivatives as Potent Non-Nucleoside Reverse Transcriptase Inhibitors Featuring Significantly Improved Anti-Resistance Efficacy(2023)
Authors: Christophe Pannecouque, Erik De Clercq
Pages: 4755 - 4767
Patents
1 - 7 of 7
- Phosphonate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production (Inventor)
- 6-[2-(PHOSPHONOMETHOXY)ALKOXY] PYRIMIDINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY (Inventor)
- Phosphonate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production (Inventor)
- Phosponate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production (Inventor)
- VIRAL INHIBITORS (Inventor)
- VIRAL INHIBITORS (Inventor)
- PHOSPHONATE NUCLEOSIDES USEFUL AS ACTIVE INGREDIENTS IN PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS, AND INTERMEDIATES FOR THEIR PRODUCTION (Inventor)