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Researcher
Erik De Clercq
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 1999 → 30 Sep 2013
Publications
31 - 40 of 564
- Disubstituted pyrimidine-5-carboxamide derivatives as novel HIV-1 NNRTIs: Crystallographic overlay-based molecular design, synthesis, and biological evaluation(2023)
Authors: Erik De Clercq, Christophe Pannecouque
- Therapeutic strategies for human poxvirus infections: Monkeypox (mpox), smallpox, molluscipox, and orf.(2023)
Authors: Erik De Clercq
Pages: 102528 - Covalently Targeted Highly Conserved Tyr318 to Improve the Drug Resistance Profiles of HIV-1 NNRTIs: A Proof-of-Concept Study(2023)
Authors: Erik De Clercq, Christophe Pannecouque
- Immune repertoire sequencing reveals an abnormal adaptive immune system in COVID-19 survivors(2023)
Authors: Erik De Clercq
- The development of BVDU: An odyssey.(2023)
Authors: Erik De Clercq
Pages: 2040206623 - Lead Optimization and Avoidance of Metabolic-perturbing Motif Developing Novel Diarylpyrimidines as Potent HIV-1 NNRTIs(2022)
Authors: Erik De Clercq, Christophe Pannecouque
Pages: 15608 - 15626 - Discovery and Mechanistic Investigation of Piperazinone Phenylalanine Derivatives with Terminal Indole or Benzene Ring as Novel HIV-1 Capsid Modulators(2022)
Authors: Erik De Clercq, Christophe Pannecouque
- Discovery of novel 1,2,4-triazole phenylalanine derivatives targeting an unexplored region within the interprotomer pocket of the HIV capsid protein(2022)
Authors: Erik De Clercq, Christophe Pannecouque
Pages: 5975 - 5986 - Design, Synthesis, and Mechanistic Study of 2-Pyridone-Bearing Phenylalanine Derivatives as Novel HIV Capsid Modulators(2022)
Authors: Erik De Clercq, Christophe Pannecouque
- Identification of Novel Diarylpyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors by Exploring the Primer Grip Region(2022)
Authors: Erik De Clercq, Christophe Pannecouque
Patents
1 - 7 of 7
- Phosphonate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production (Inventor)
- 6-[2-(PHOSPHONOMETHOXY)ALKOXY] PYRIMIDINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY (Inventor)
- Phosphonate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production (Inventor)
- Phosponate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production (Inventor)
- VIRAL INHIBITORS (Inventor)
- VIRAL INHIBITORS (Inventor)
- PHOSPHONATE NUCLEOSIDES USEFUL AS ACTIVE INGREDIENTS IN PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS, AND INTERMEDIATES FOR THEIR PRODUCTION (Inventor)